Research Article
Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer
Table 3
Correlations between HSP90s gene expression and biomarker expression of subsets of TIICs in BRAC from the GEPIA.
| | Types of TIICs | Biomarker | HSP90AA1 | HSP90AB1 | HSP90B1 | TRAP1 | | | | | | | | |
| | B cell | CD19 | -0.17 | 2.20-08 | -0.19 | 5.20-10 | -0.08 | 5.50-03 | -0.11 | 4.40-04 | | CD79A | -0.18 | 9.00-10 | -0.18 | 5.30-09 | -0.11 | 2.60-04 | -0.15 | 1.30-06 |
| | T cell (general) | CD3D | -0.22 | 9.70-14 | -0.23 | 3.00-14 | -0.08 | 5.90-03 | -0.17 | 7.60-09 | | CD3E | -0.18 | 1.90-09 | -0.19 | 3.50-10 | -0.07 | 1.70-02 | -0.19 | 2.70-10 | | CD2 | -0.12 | 1.40-04 | -0.13 | 1.20-05 | -0.03 | 3.60-01 | -0.17 | 2.00-08 |
| | Th1 | TBX21 | -0.17 | 2.80-08 | -0.15 | 3.50-07 | -0.04 | 1.90-01 | -0.15 | 6.40-07 | | STAT4 | -0.09 | 4.50-03 | -0.14 | 3.80-06 | -0.03 | 3.80-01 | -0.22 | 1.30-13 | | STAT1 | 0.29 | 3.10-22 | 0.26 | 1.10-17 | 0.27 | 4.60-19 | -0.01 | 7.20-01 | | TNF | -0.01 | 7.00-01 | 0.05 | 1.20-01 | 0.11 | 5.10-04 | 0.10 | 7.90-04 | | IFNG | -0.02 | 5.40-01 | -0.02 | 4.80-01 | 0.10 | 1.10-03 | -0.11 | 1.90-04 |
| | Th2 | GATA3 | 0.13 | 1.50-05 | 0.13 | 1.20-05 | -0.11 | 3.30-04 | 0.13 | 1.20-05 | | STAT6 | 0.10 | 8.70-04 | 0.07 | 2.30-02 | -0.06 | 4.20-02 | 0.10 | 1.60-03 | | IL13 | -0.03 | 3.10-01 | -0.03 | 2.90-01 | 0.00 | 9.40-01 | -0.07 | 1.60-02 | | STAT5A | -0.16 | 1.80-07 | -0.10 | 8.40-04 | -0.10 | 6.70-04 | 0.05 | 9.20-02 |
| | Tfh | BCL6 | 0.03 | 3.60-01 | -0.02 | 5.00-01 | -0.04 | 2.50-01 | -0.02 | 5.50-01 | | IL21 | 0.08 | 1.30-02 | 0.06 | 4.60-02 | 0.09 | 3.30-03 | -0.11 | 2.30-04 |
| | Th17 | STAT3 | 0.25 | 1.60-17 | 0.20 | 7.80-11 | 0.14 | 6.40-06 | 0.13 | 3.00-05 | | IL17A | 0.00 | 8.80-01 | 0.02 | 5.10-01 | 0.07 | 2.20-02 | -0.08 | 6.20-03 |
| | Treg | FOXP3 | -0.01 | 7.60-01 | -0.02 | 4.20-01 | 0.02 | 5.10-01 | -0.10 | 1.00-03 | | CCR8 | 0.22 | 1.00-13 | 0.19 | 3.00-10 | 0.14 | 8.10-06 | -0.05 | 1.30-01 | | TGFB1 | -0.22 | 5.50-13 | -0.24 | 3.10-16 | -0.18 | 2.50-09 | -0.14 | 7.00-06 |
| | CD8+ T | CD8A | -0.13 | 1.60-05 | -0.13 | 8.40-06 | -0.05 | 1.10-01 | -0.17 | 9.70-09 | | CD8B | -0.16 | 2.50-07 | -0.17 | 2.20-08 | -0.06 | 6.80-02 | -0.13 | 1.40-05 |
| | T cell exhaustion | PDCD1 | -0.17 | 9.30-09 | -0.15 | 1.20-06 | -0.06 | 5.30-02 | -0.11 | 1.70-04 | | CTLA4 | -0.05 | 1.40-01 | -0.05 | 8.20-02 | 0.07 | 2.70-02 | -0.10 | 1.10-03 | | LAG3 | -0.10 | 1.60-03 | -0.05 | 9.10-02 | 0.05 | 9.00-02 | -0.03 | 3.00-01 | | TIM3 | 0.09 | 3.70-03 | 0.03 | 3.30-01 | 0.13 | 1.30-05 | -0.12 | 1.30-04 | | GZMB | -0.10 | 5.70-04 | -0.09 | 3.00-03 | 0.06 | 4.20-02 | -0.11 | 1.90-04 |
| | NK cell | KIR2DL1 | -0.02 | 5.40-01 | 0.00 | 8.90-01 | 0.10 | 6.90-04 | -0.11 | 4.70-04 | | KIR3DL3 | 0.00 | 9.10-01 | 0.04 | 2.50-01 | 0.10 | 6.50-04 | -0.02 | 4.60-01 | | KIR3DL1 | -0.08 | 1.20-02 | -0.07 | 2.10-02 | 0.04 | 1.70-01 | -0.12 | 4.80-05 | | KIR3DL2 | -0.06 | 3.70-02 | -0.04 | 2.20-01 | 0.03 | 3.60-01 | -0.11 | 2.20-04 | | KIR3DL3 | 0.00 | 9.10-01 | 0.04 | 2.50-01 | 0.10 | 6.50-04 | -0.02 | 4.60-01 | | KIR2DS4 | -0.03 | 3.00-01 | -0.03 | 3.50-01 | 0.03 | 3.30-01 | -0.14 | 4.90-06 |
| | Neutrophils | CD11b | 0.00 | 9.40-01 | -0.06 | 4.90-02 | -0.01 | 7.20-01 | 0.01 | 6.90-01 | | CCR7 | -0.13 | 9.80-06 | -0.12 | 1.20-04 | -0.11 | 2.70-04 | -0.14 | 2.10-06 | | CD66b | 0.00 | 1.00+00 | -0.03 | 4.10-01 | 0.03 | 3.10-01 | -0.03 | 2.60-01 |
| | M1 macrophages | NOS2 | 0.08 | 1.10-02 | 0.11 | 4.20-04 | 0.05 | 1.40-01 | -0.06 | 5.40-02 | | PTGS2 | -0.04 | 1.90-01 | -0.06 | 3.60-02 | 0.04 | 2.10-01 | -0.17 | 7.60-09 | | IRF5 | 0.00 | 9.50-01 | 0.08 | 8.20-03 | 0.14 | 6.00-06 | 0.00 | 8.70-01 |
| | M2 macrophages | CD163 | 0.02 | 4.20-01 | 0.04 | 1.90-01 | 0.15 | 8.40-07 | -0.09 | 2.20-03 | | VSIG4 | 0.01 | 7.10-01 | 0.00 | 8.90-01 | 0.08 | 1.10-02 | -0.10 | 5.50-04 | | MS4A4A | 0.06 | 6.70-02 | 0.02 | 4.90-01 | 0.10 | 1.80-03 | -0.15 | 3.50-07 |
| | TAM | CCL2 | -0.05 | 1.20-01 | -0.07 | 3.40-02 | 0.08 | 1.20-02 | -0.15 | 4.50-07 | | CD68 | 0.15 | 3.40-07 | 0.10 | 1.50-03 | 0.08 | 1.20-02 | -0.07 | 1.90-02 | | IL10 | 0.14 | 3.00-06 | 0.11 | 1.90-04 | 0.14 | 7.80-06 | -0.09 | 4.10-03 |
| | Monocyte | CD86 | 0.07 | 3.20-02 | 0.03 | 3.50-01 | 0.15 | 3.60-07 | -0.14 | 2.00-06 | | CD115 | -0.09 | 3.00-03 | -0.08 | 8.40-03 | 0.03 | 3.50-01 | -0.13 | 2.30-05 |
| | DC | HLA-DPB1 | -0.25 | 2.20-16 | -0.26 | 7.70-18 | -0.14 | 1.80-06 | -0.16 | 5.70-08 | | HLA-DRA | -0.08 | 9.60-03 | -0.13 | 8.70-06 | -0.01 | 7.20-01 | -0.16 | 6.80-08 | | HLA-DQB1 | -0.20 | 6.80-11 | -0.20 | 1.40-11 | -0.06 | 5.00-02 | -0.09 | 4.30-03 | | HLA-DPA1 | -0.09 | 5.20-03 | -0.14 | 2.80-06 | -0.02 | 6.10-01 | -0.16 | 4.60-08 | | CD1C | -0.24 | 6.90-16 | -0.24 | 2.80-16 | -0.20 | 1.90-11 | -0.18 | 3.20-09 | | NRP1 | 0.12 | 8.30-05 | 0.01 | 8.00-01 | 0.02 | 5.10-01 | -0.20 | 1.70-11 | | CD11c | -0.07 | 2.80-02 | -0.09 | 4.20-03 | -0.03 | 3.20-01 | -0.08 | 5.90-03 |
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Note: the same as Table 2. |
