|
| Pathway | DHF | nDHF |
| Count (%) | value | Gene | Count (%) | value | Gene |
|
| Biosynthesis of antibiotics | 33 (2.30) | | BCAT1/LDHB/EHHADH/ALDOC/OGDHL/PGAM2/ECHS1/OGDH/ACAT1/PDHB/CMBL/GOT2/GOT1/IDH3G/ATIC/RGN/PDHA1/NSDHL/DLST/ACO2/CS/IDH3B/PFKM/PYCR1/G6PD/HMGCS2/SDHC/DLD/PCYOX1/PCCB/MDH2/PRPS2/ACAA1 | 29 (1.86) | | SC5D/ADH5/ACSS2/PSPH/ACAT1/HADHA/PDHB/CMBL/ACSS1/IDH2/SUCLA2/HADH/FH/ACAA2/ACO2/CS/BCKDHB/FBP1/DLAT/PFKM/AK9/IDH3A/SDHA/GPI/ALDH7A1/SDHC/PGM1/ALDH2/PCYOX1 |
| Metabolic pathways | 116 (8.07) | | LDHB/EHHADH/NDUFAB1/PGAM2/OGDH/PDHB/HIBADH/MTHFD1L/CMBL/GOT2/GOT1/IDH3G/ST3GAL5/ST3GAL4/RGN/PDHA1/BST1/LPCAT4/CD38/PYCR1/NNT/DLD/PCCB/PRPS2/MDH2/ACAA1/ACADSB/ME3/ALDOC/ACSBG2/ACAT1/B4GALT6/UPB1/MAOB/SPHK1/ACMSD/IDH3B/ACACB/NDUFV3/GGT5/HMGCS2/PLCG2/COX6A1/BCO1/PHYKPL/UQCRC2/ETNPPL/COX11/COX10/OGDHL/ACOT2/QARS/MTHFD1/MCCC2/ALAS1/NDUFS4/PLCB4/XYLT1/MCEE/MCCC1/PIGC/AGPAT4/PTDSS1/NDUFS3/NDUFS2/NDUFS1/HYAL1/ACO2/ALDH5A1/NADSYN1/COX4I1/PIGS/PFKM/NDUFA10/PIGO/COQ6/ACADVL/COQ2/G6PD/CKM/PRDX6/PANK1/INPP4A/BCAT1/NDUFB6/ALDH18A1/NDUFB8/NDUFB9/NFS1/ECHS1/COMT/AZIN2/TYMS/ATIC/DHCR7/ALDH1A3/CKMT2/CYP26B1/GALNT16/BDH1/AGL/INPP5A/NSDHL/DLST/NDUFA2/NDUFA8/NDUFA9/NDUFA6/CS/MPI/PYGM/SDHC/AKR1B1/LIPG/DPM2/SCP2 | 105 (6.75) | | SC5D/GNPDA1/PTGS2/CNDP2/DTYMK/ACSS2/PDHB/CMBL/FAHD1/ACSS1/CPOX/HADH/GPT2/ACAA2/FBP1/QDPR/LPCAT4/EARS2/CD38/CHPF/PGM1/MGAT5/GATB/GATC/LALBA/COASY/GCNT2/GLUD2/ACAT1/HADHA/POLE2/IDH2/DHODH/CDA/AMD1/FH/MGAT4B/MOCS2/B4GAT1/UPB1/MAOB/DLAT/RIMKLA/IDH3A/AK9/ALDH2/COX6A1/NNMT/COX10/ACOT2/PIP5K1B/PSPH/MCCC2/ST6GALNAC6/ALAS1/PLCB4/ACAD8/PTDSS1/SUCLA2/AGPAT3/NDUFS2/POLR1E/CYP11A1/ACO2/ALDH5A1/ACADS/ATP6V1H/PFKM/COQ7/ST6GALNAC1/MAN2A2/ALDH7A1/MTMR14/ADK/GPAM/UQCRB/POLR2H/TYRP1/NFS1/ADH5/ATP6V1G1/PLPP1/NDUFB1/CBR1/CKMT2/PLCD3/GALNT16/UCK2/PAFAH1B2/PDHX/AGL/EBP/POLR3F/MTHFD2L/B3GALT2/NDUFA9/BCKDHB/CS/POLR3GL/DGKI/SDHA/GPI/PYGM/SDHC/LTA4H |
| Citrate cycle (TCA cycle) | 12 (0.83) | | DLST/IDH3G/ACO2/SDHC/DLD/OGDHL/CS/IDH3B/PDHA1/OGDH/MDH2/PDHB | 10 (0.64) | | SDHA/ACO2/SDHC/CS/IDH2/DLAT/SUCLA2/IDH3A/PDHB/FH |
| Malaria | 10 (0.70) | | VCAM1/CCL2/COMP/TGFB3/THBS1/THBS2/IL10/TGFB1/SDC2/TGFB2 | 8 (0.51) | | VCAM1/ITGAL/IL6/CCL2/IL18/THBS2/SELE/TGFB2 |
| Valine, leucine, and isoleucine degradation | 14 (0.97) | | BCAT1/ACADSB/EHHADH/ECHS1/ACAT1/HIBADH/MCCC2/HMGCS2/MCCC1/MCEE/DLD/AACS/PCCB/ACAA1 | 10 (0.64) | | ACAA2/MCCC2/ALDH7A1/ACADS/BCKDHB/ALDH2/ACAD8/HADH/ACAT1/HADHA |
| Butanoate metabolism | 7 (0.49) | | HMGCS2/ALDH5A1/EHHADH/ECHS1/AACS/BDH1/ACAT1 | 6 (0.39) | | L2HGDH/ALDH5A1/ACADS/HADH/ACAT1/HADHA |
| Carbon metabolism | 26 (1.81) | | ME3/EHHADH/ALDOC/OGDHL/ECHS1/PGAM2/OGDH/ACAT1/PDHB/GOT2/IDH3G/GOT1/MCEE/RGN/PDHA1/DLST/ACO2/CS/IDH3B/PFKM/G6PD/SDHC/DLD/PCCB/MDH2/PRPS2 | 22 (1.41) | | ACO2/ACADS/GLUD2/CS/ADH5/FBP1/PFKM/DLAT/PSPH/ACSS2/ACAT1/HADHA/IDH3A/PDHB/SDHA/GPI/ACSS1/SDHC/IDH2/SUCLA2/GPT2/FH |
| HIF-1 signaling pathway | 14 (0.97) | | CAMK2G/RPS6/PDHB/TIMP1/RBX1/CDKN1A/PLCG2/SERPINE1/TEK/PDHA1/PIK3R3/EGF/NPPA/AKT2 | 11 (0.71) | | PDK1/IL6/BCL2/MAPK3/EDN1/SERPINE1/IGF1/IFNGR2/NPPA/PDHB/TIMP1 |
| Pyruvate metabolism | 9 (0.63) | | LDHB/ME3/DLD/LDHD/PDHA1/ACACB/ACAT1/MDH2/PDHB | 9 (0.58) | | ALDH7A1/ACSS1/LDHD/ALDH2/DLAT/ACSS2/ACAT1/PDHB/FH |
| TGF-β signaling pathway | 11 (0.77) | | LTBP1/GDF6/TGFBR1/TGFB3/ID4/BMPR1B/THBS1/TGFB1/TGFB2/BMP8A/RBX1 | 11 (0.71) | | INHBB/SMAD9/E2F5/SMAD7/SMAD6/MAPK3/ID4/ID3/TGFB2/BMP8A/BMP6 |
| Calcium signaling pathway | 18 (1.25) | | ORAI2/ADORA2B/ERBB4/CAMK2G/SPHK1/HTR4/PTGFR/VDAC3/VDAC1/CD38/PLCB4/ATP2A2/P2RX1/PDE1C/P2RX3/PLCG2/RYR2/F2R | 19 (1.22) | | SLC25A4/SLC25A5/MYLK3/PHKA1/PTGFR/VDAC2/GRM1/CD38/AGTR1/ADRB2/PLCB4/ADRB1/PDE1C/AVPR1A/PLCD3/ADRA1A/RYR2/CHRNA7/HTR2B |
| Fatty acid degradation | 9 (0.63) | | CPT1C/ACADVL/ECI2/ACADSB/EHHADH/ACSBG2/ECHS1/ACAT1/ACAA1 | 9 (0.58) | | CPT1C/ACAA2/ALDH7A1/ACADS/ADH5/ALDH2/HADH/ACAT1/HADHA |
| 2-Oxocarboxylic acid metabolism | 7 (0.49) | | GOT2/BCAT1/GOT1/IDH3G/ACO2/CS/IDH3B | 5 (0.32) | | ACO2/CS/IDH2/GPT2/IDH3A |
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