USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway

<div>USP46 promoted PHLPP1 protein stability via deubiquitination in human lung cancer cells. (a, b) mRNA levels of PHLPP1 in A549 and H1299 cells upon USP46 overexpression (a) and USP46 knockdown (b) were measured by RT-PCR. 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376V378Z"></path></g></svg>).</span> (c) Interaction between USP46 and PHLPP1 was tested by co-IP followed by WB using indicated antibodies. (d) USP46-dependent ubiquitination in PHLPP1 was measured by comparing ubiquitination in PHLPP1 in USP46 overexpressing cells (oeUSP46) and control cells (oeNC).</div>

BioMed Research International

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Figure 3

Figure 3: USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway 