Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics Approach

Table 3

The most promising MHC class II-related peptides in the envelope protein-based vaccine of COVID-19 along with the predicted coverage of the world, China, Europe, and East Asia.

Peptide sequence	Alleles	World coverage	Coverage/10 peptides
KPSFYVYSRVKNLNS	HLA-DPA101:03, HLA-DPB102:01, HLA-DPB103:01, HLA-DPB104:01, HLA-DPA102:01, HLA-DPB105:01, HLA-DPA103:01, HLA-DPB104:02, HLA-DPB106:01, HLA-DPB114:01, HLA-DPB101:01, HLA-DQA105:01, HLA-DQB104:02, HLA-DQA106:01, HLA-DQA101:02, HLA-DQB105:01, HLA-DQA102:01, HLA-DRB101:01, HLA-DRB107:01, HLA-DRB108:01, HLA-DRB109:01, HLA-DRB111:01, HLA-DRB401:03, HLA-DRB104:01, HLA-DRB110:01, HLA-DRB104:05, HLA-DRB113:01, HLA-DRB108:02, HLA-DRB116:02, HLA-DRB115:01, HLA-DRB303:01, HLA-DRB501:01, HLA-DRB302:02, HLA-DRB104:04, HLA-DRB113:02	99.93%	World: 99.99%
VKPSFYVYSRVKNLN	HLA-DPA101:03, HLA-DPB102:01, HLA-DPB104:01, HLA-DPB103:01, HLA-DPA102:01, HLA-DPB105:01, HLA-DPA103:01, HLA-DPB104:02, HLA-DPB106:01, HLA-DPB101:01, HLA-DQA105:01, HLA-DQB104:02, HLA-DQA106:01, HLA-DQA101:02, HLA-DQB105:01, HLA-DQA102:01, HLA-DRB107:01, HLA-DRB108:01, HLA-DRB101:01, HLA-DRB109:01, HLA-DRB111:01, HLA-DRB401:03, HLA-DRB115:01, HLA-DRB113:01, HLA-DRB303:01, HLA-DRB110:01, HLA-DRB116:02, HLA-DRB108:02, HLA-DRB104:05, HLA-DRB501:01, HLA-DRB113:02, HLA-DRB302:02, HLA-DRB104:01, HLA-DRB104:04	99.92%	China: 99.96%
LVKPSFYVYSRVKNL	HLA-DPA101:03, HLA-DPB102:01, HLA-DPB104:01, HLA-DPA102:01, HLA-DPB105:01, HLA-DPB106:01, HLA-DPA103:01, HLA-DPB104:02, HLA-DPA102:01, HLA-DPB101:01, HLA-DQA106:01, HLA-DQB104:02, HLA-DQA105:01, HLA-DQA102:01, HLA-DQA101:04, HLA-DQB105:03, HLA-DQA101:02, HLA-DQB105:01, HLA-DRB107:01, HLA-DRB108:01, HLA-DRB109:01, HLA-DRB111:01, HLA-DRB401:03, HLA-DRB303:01, HLA-DRB101:01, HLA-DRB115:01, HLA-DRB116:02, HLA-DRB113:01, HLA-DRB110:01, HLA-DRB108:02, HLA-DRB501:01, HLA-DRB113:02, HLA-DRB104:05, HLA-DRB302:02, HLA-DRB104:01	99.90%	Europe: 100.0%
PSFYVYSRVKNLNSS	HLA-DPA101:03, HLA-DPB102:01, HLA-DPB103:01, HLA-DPB104:01, HLA-DPA103:01, HLA-DPB104:02, HLA-DPA102:01, HLA-DPB105:01, HLA-DPB106:01, HLA-DQA105:01, HLA-DQB104:02, HLA-DQA101:02, HLA-DQB105:01, HLA-DQA106:01, HLA-DRB101:01, HLA-DRB108:01, HLA-DRB104:01, HLA-DRB111:01, HLA-DRB109:01, HLA-DRB107:01, HLA-DRB401:03, HLA-DRB104:05, HLA-DRB110:01, HLA-DRB113:01, HLA-DRB108:02, HLA-DRB116:02, HLA-DRB115:01, HLA-DRB303:01, HLA-DRB302:02, HLA-DRB104:04, HLA-DRB501:01, HLA-DRB113:02	99.86%	East Asia:99.91%
NIVNVSLVKPSFYVY	HLA-DPA101:03, HLA-DPB102:01, HLA-DPB104:01, HLA-DPB106:01, HLA-DPA102:01, HLA-DPB101:01, HLA-DQA101:02, HLA-DQB105:01, HLA-DQA105:01, HLA-DQB104:02, HLA-DQA102:01, HLA-DQB103:01, HLA-DQB103:03, HLA-DQB103:03, HLA-DQB104:02, HLA-DRB112:01, HLA-DRB101:01, HLA-DRB501:01, HLA-DRB303:01, HLA-DRB113:01, HLA-DRB107:01, HLA-DRB115:01, HLA-DRB401:03, HLA-DRB104:04, HLA-DRB108:02, HLA-DRB109:01, HLA-DRB113:02, HLA-DRB111:01, HLA-DRB104:05, HLA-DRB110:01	99.77%
LLVTLAILTALRLCA	HLA-DPA101:03, HLA-DPB102:01, HLA-DPB106:01, HLA-DPA103:01, HLA-DPB104:02, HLA-DQA101:02, HLA-DQB105:01, HLA-DQA102:01, HLA-DQB103:01, HLA-DQB103:03, HLA-DQA105:01, HLA-DQB104:02, HLA-DQA106:01, HLA-DQA101:03, HLA-DQB106:03, HLA-DRB401:03, HLA-DRB101:01, HLA-DRB113:01, HLA-DRB104:04, HLA-DRB501:01, HLA-DRB303:01, HLA-DRB110:01, HLA-DRB115:01, HLA-DRB107:01, HLA-DRB111:01, HLA-DRB108:01, HLA-DRB112:01, HLA-DRB103:01, HLA-DRB401:01, HLA-DRB116:02, HLA-DRB108:02	99.72%
SFYVYSRVKNLNSSR	HLA-DPA101:03, HLA-DPB103:01, HLA-DPB102:01, HLA-DPA103:01, HLA-DPB104:02, HLA-DPA102:01, HLA-DPB105:01, HLA-DPB106:01, HLA-DQA105:01, HLA-DQB104:02, HLA-DQA101:02, HLA-DQB105:01, HLA-DRB104:01, HLA-DRB101:01, HLA-DRB111:01, HLA-DRB108:01, HLA-DRB107:01, HLA-DRB109:01, HLA-DRB401:03, HLA-DRB110:01, HLA-DRB113:01, HLA-DRB104:05, HLA-DRB108:02, HLA-DRB116:02, HLA-DRB302:02, HLA-DRB303:01, HLA-DRB104:04, HLA-DRB115:01, HLA-DRB501:01, HLA-DRB113:02	99.72%
LVTLAILTALRLCAY	HLA-DPA101:03, HLA-DPB102:01, HLA-DPB106:01, HLA-DPA103:01, HLA-DPB104:02, HLA-DQA101:02, HLA-DQB105:01, HLA-DQA102:01, HLA-DQB103:01, HLA-DQB103:03, HLA-DQA105:01, HLA-DQB104:02, HLA-DQB106:02, HLA-DQA102:01, HLA-DQA106:01, HLA-DRB401:03, HLA-DRB101:01, HLA-DRB113:01, HLA-DRB104:04, HLA-DRB112:01, HLA-DRB110:01, HLA-DRB501:01, HLA-DRB115:01, HLA-DRB111:01, HLA-DRB303:01, HLA-DRB103:01, HLA-DRB108:01, HLA-DRB107:01, HLA-DRB401:01, HLA-DRB116:02, HLA-DRB104:02, HLA-DRB108:02	99.69%
VTLAILTALRLCAYC	HLA-DPA101:03, HLA-DPB106:01, HLA-DPA103:01, HLA-DPB104:02, HLA-DQA102:01, HLA-DQB103:01, HLA-DQA101:02, HLA-DQB105:01, HLA-DQB106:02, HLA-DQA105:01, HLA-DQB104:02, HLA-DQB103:03, HLA-DQA106:01, HLA-DQB104:02, HLA-DRB101:01, HLA-DRB401:03, HLA-DRB113:01, HLA-DRB104:04, HLA-DRB112:01, HLA-DRB110:01, HLA-DRB501:01, HLA-DRB115:01, HLA-DRB111:01, HLA-DRB103:01, HLA-DRB303:01, HLA-DRB108:01, HLA-DRB107:01, HLA-DRB401:01, HLA-DRB104:02	99.56%
CNIVNVSLVKPSFYV	HLA-DPA101:03, HLA-DPB106:01, HLA-DPB104:02, HLA-DQA101:02, HLA-DQB105:01, HLA-DQA105:01, HLA-DQB104:02, HLA-DQA102:01, HLA-DQB103:01, HLA-DQB103:03, HLA-DQA101:03, HLA-DQB106:03, HLA-DRB303:01, HLA-DRB112:01, HLA-DRB501:01, HLA-DRB101:01, HLA-DRB107:01, HLA-DRB401:03, HLA-DRB113:01, HLA-DRB115:01, HLA-DRB108:02, HLA-DRB104:04, HLA-DRB109:01, HLA-DRB113:02, HLA-DRB111:01, HLA-DRB104:05, HLA-DRB401:01, HLA-DRB110:01	99.53%