Research Article
Development of an Immune Infiltration-Related Eight-Gene Prognostic Signature in Colorectal Cancer Microenvironment
Table 3
Univariate and multivariate Cox regression analyses in a TCGA-CRC cohort.
| | Characteristics | Univariate analysis | Multivariate analysis | | HR (95% CI) | value | HR (95% CI) | value |
| | Stromal score | 1 (1-1) | 0.653 | NA | NA | | Immune score | 1 (1-1) | 0.941 | NA | NA | | Age | 1.396 (0.878-2.22) | 0.158 | NA | NA | | Gender | 1.127 (0.751-1.692) | 0.564 | NA | NA | | Tumor stage | 3.064 (1.986-4.726) | <0.0001 | 3.320 (0.870-12.640) | 0.079 | | Pathologic T | 3.204 (1.398-7.345) | 0.006 | 4.914 (0) | 0.996 | | Pathologic N | 2.581 (1.705-3.909) | <0.0001 | 0.920 (0.290-2.890) | 0.880 | | Pathologic M | 3.519 (2.312-5.356) | <0.0001 | 1.620 (0.84-3.13) | 0.151 | | MMR | 0.181 (0.044-0.751) | 0.019 | 0.070 (0.010-0.500) | 0.009 | | BRAF | 1.108 (0.620-1.980) | 0.729 | NA | NA | | KRAS | 0.912 (0.580-1.434) | 0.691 | NA | NA | | TP53 | 1.461 (0.884-2.417) | 0.139 | NA | NA | | MSI | 0.907 (0.522-1.575) | 0.728 | NA | NA | | Risk score | 2.718 (2.063-3.581) | <0.0001 | 2.420 (1.590-3.700) | <0.0001 |
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NA: not available.
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