lncRNA RP11-838N2.3 Promoted Cisplatin Resistance in Lung Adenocarcinoma

Figure 7

Knockdown of RP11-838N2.3 could inhibit proliferation efficiency of A549/DDP. (a) Compared with that of 0 h, the relative widths of 24 h (, , , and ), 48 h (, , , and ), 72 h (, , , and ) decreased obviously and the mobility increased evidently. Compared with that of the A54/DDP shRNA-NC group, the relative widths of the A549/DDP shRNA group in 24 h (, ), 48 h (, ), and 72 h (, ) increased obviously, and the mobility decreased clearly. These results showed that RP11-838N2.3 knockdown obviously inhibited the migration of A549/DDP cells. (b) Under the action of cisplatin drugs, RP11-838N2.3 knockdown can still clearly inhibit the migration of A549/DDP cells. Compared with that of the A549/DDP shRNA-NC+2 μg/ml cisplatin group, the relative widths of the A549/DDP shRNA+2 μg/ml cisplatin group in 24 h (F =2.129, ), 48 h (F =2.919, ), and 72 h (F =5.460, P <0.001) increased clearly. .

(a)

(b)