BioMed Research International / 2020 / Article / Tab 1

Review Article

miR-19 Is a Potential Clinical Biomarker for Gastrointestinal Malignancy: A Systematic Review and Meta-analysis

Table 1

Main characteristics and results of the included studies.

StudyYearCountry or areaSample numberAgeDetection methodCut-off pointHistologyStageFollow-up period (month)Survival

Yamada2015USA48NRRT-PCR>medianCRCNRNRNR
Kahlert2011Germany29NRRT-PCRNRCRCNR60OS, RFS
Cellura2015UK10NRRT-PCR≥medianCRCNRNRNR
Huang2015China27560 (mean)RT-PCR≥0.22CRCI-IVNROS
Jiang2017China21165 (mean)RT-PCR>medianCRCI-IV59 (median)OS, DFS
Mastumura2015Japan20965 (mean)RT-PCRNRCRCI-IV60OS, DFS
Cruz-Gil2018Spain126NRRT-PCRNRCRCII-IIINRDFS
Koga2010Japan6260 (median)RT-PCR>medianCRCNRNRNR
Zhu2017China16660 (mean)RT-PCR>medianCRCI-IVNRNR
Zhang2018China5660 (mean)RT-PCR>medianCRCI-IV80OS
Yin2019China3050 (mean)RT-PCR>medianCRCI-IVNRNR
Marcuello2019Spain5962 (mean)RT-PCRNRCRCI-IVNRNR
Guo2014China5150 (mean)RT-PCR>medianHCCI-IV60OS
Han2012China10556.5 (mean)RT-PCRNRHCCI-IV80OS, DFS
Hu2018China20NRRT-PCR>medianHCCNRNRNR
Hung2015Taiwan8160 (mean)RT-PCR≥medianHCCII-IV37 (mean)OS, DFS
Yu2016China43NRRT-PCR≥medianHCCNRNRNR
Zhang2015China13050 (mean)RT-PCR≥medianHCCI-IV60OS, DFS
Zhu2010China9550 (mean)RT-PCRHCCI-III62.6 (mean)OS
Jiang2018China22NRRT-PCR≥medianHCCNRNRNR
Cai2016China60NRRT-PCR>medianGCNRNRNR
Li2014China3050 (mean)RT-PCRNRGCI-IVNRNR
Ibarrola-Villava2015Spain45NRRT-PCR≥medianGCNRNRNR
Wang2016China9065 (mean)RT-PCR>medianGCI-IV60OS, DFS
Wang2017China12060RT-PCRGCI-IVNRNR
Wu2014China14160 (mean)RT-PCR≥medianGCI-IV70OS
Zhu2018China18060 (mean)RT-PCRGCI-IVNRNR
Liu2018China8065.1 (mean)RT-PCR2.072GCI-IVNRNR
Li2018China42NRRT-PCR≥medianGCNRNRNR
Zhu2019China40NRRT-PCR≥medianGCNRNRNR
Peng2018China33359.42 (mean)RT-PCR≥medianGCI-IV60OS, PFS
Xu2014China10555 (mean)RT-PCRECI-IV34.5 (median)OS, PFS
Bai2017China8958 (mean)RT-PCR≥0.2909ECI-IVNRNR
Tan2015China58NRRT-PCR≥medianPCNRNROS
Qu2014China3965 (mean)RT-PCRNRPCI-IVNRNR
Zou2019China12960 (mean)RT-PCR>medianPCI-IVNROS
Hu2016China63NRRT-PCR≥medianPCNRNRNR

Abbreviations: NR: not reported; RT-PCR: real-time polymerase chain reaction; T/N: tumor/normal; CRC: colorectal cancer; EC: esophagus cancer; GC: gastric cancer; PC: pancreatic cancer; LC: liver cancer; OS: overall survival; DFS: disease-free survival; RFS: recurrence-free survival; PFS: progression-free survival.

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