miR-19 Is a Potential Clinical Biomarker for Gastrointestinal Malignancy: A Systematic Review and Meta-analysis

Table 1

Main characteristics and results of the included studies.

Study	Year	Country or area	Sample number	Age	Detection method	Cut-off point	Histology	Stage	Follow-up period (month)	Survival
Yamada	2015	USA	48	NR	RT-PCR	>median	CRC	NR	NR	NR
Kahlert	2011	Germany	29	NR	RT-PCR	NR	CRC	NR	60	OS, RFS
Cellura	2015	UK	10	NR	RT-PCR	≥median	CRC	NR	NR	NR
Huang	2015	China	275	60 (mean)	RT-PCR	≥0.22	CRC	I-IV	NR	OS
Jiang	2017	China	211	65 (mean)	RT-PCR	>median	CRC	I-IV	59 (median)	OS, DFS
Mastumura	2015	Japan	209	65 (mean)	RT-PCR	NR	CRC	I-IV	60	OS, DFS
Cruz-Gil	2018	Spain	126	NR	RT-PCR	NR	CRC	II-III	NR	DFS
Koga	2010	Japan	62	60 (median)	RT-PCR	>median	CRC	NR	NR	NR
Zhu	2017	China	166	60 (mean)	RT-PCR	>median	CRC	I-IV	NR	NR
Zhang	2018	China	56	60 (mean)	RT-PCR	>median	CRC	I-IV	80	OS
Yin	2019	China	30	50 (mean)	RT-PCR	>median	CRC	I-IV	NR	NR
Marcuello	2019	Spain	59	62 (mean)	RT-PCR	NR	CRC	I-IV	NR	NR
Guo	2014	China	51	50 (mean)	RT-PCR	>median	HCC	I-IV	60	OS
Han	2012	China	105	56.5 (mean)	RT-PCR	NR	HCC	I-IV	80	OS, DFS
Hu	2018	China	20	NR	RT-PCR	>median	HCC	NR	NR	NR
Hung	2015	Taiwan	81	60 (mean)	RT-PCR	≥median	HCC	II-IV	37 (mean)	OS, DFS
Yu	2016	China	43	NR	RT-PCR	≥median	HCC	NR	NR	NR
Zhang	2015	China	130	50 (mean)	RT-PCR	≥median	HCC	I-IV	60	OS, DFS
Zhu	2010	China	95	50 (mean)	RT-PCR		HCC	I-III	62.6 (mean)	OS
Jiang	2018	China	22	NR	RT-PCR	≥median	HCC	NR	NR	NR
Cai	2016	China	60	NR	RT-PCR	>median	GC	NR	NR	NR
Li	2014	China	30	50 (mean)	RT-PCR	NR	GC	I-IV	NR	NR
Ibarrola-Villava	2015	Spain	45	NR	RT-PCR	≥median	GC	NR	NR	NR
Wang	2016	China	90	65 (mean)	RT-PCR	>median	GC	I-IV	60	OS, DFS
Wang	2017	China	120	60	RT-PCR		GC	I-IV	NR	NR
Wu	2014	China	141	60 (mean)	RT-PCR	≥median	GC	I-IV	70	OS
Zhu	2018	China	180	60 (mean)	RT-PCR		GC	I-IV	NR	NR
Liu	2018	China	80	65.1 (mean)	RT-PCR	2.072	GC	I-IV	NR	NR
Li	2018	China	42	NR	RT-PCR	≥median	GC	NR	NR	NR
Zhu	2019	China	40	NR	RT-PCR	≥median	GC	NR	NR	NR
Peng	2018	China	333	59.42 (mean)	RT-PCR	≥median	GC	I-IV	60	OS, PFS
Xu	2014	China	105	55 (mean)	RT-PCR		EC	I-IV	34.5 (median)	OS, PFS
Bai	2017	China	89	58 (mean)	RT-PCR	≥0.2909	EC	I-IV	NR	NR
Tan	2015	China	58	NR	RT-PCR	≥median	PC	NR	NR	OS
Qu	2014	China	39	65 (mean)	RT-PCR	NR	PC	I-IV	NR	NR
Zou	2019	China	129	60 (mean)	RT-PCR	>median	PC	I-IV	NR	OS
Hu	2016	China	63	NR	RT-PCR	≥median	PC	NR	NR	NR

Abbreviations: NR: not reported; RT-PCR: real-time polymerase chain reaction; T/N: tumor/normal; CRC: colorectal cancer; EC: esophagus cancer; GC: gastric cancer; PC: pancreatic cancer; LC: liver cancer; OS: overall survival; DFS: disease-free survival; RFS: recurrence-free survival; PFS: progression-free survival.