Research Article

GDF15 Repression Contributes to 5-Fluorouracil Resistance in Human Colon Cancer by Regulating Epithelial-Mesenchymal Transition and Apoptosis

Figure 1

5-FU-resistant colon cancer cells showed increased EMT and decreased apoptosis. (a) MTS assay to detect inhibition of growth by 5-FU in HCT-15 or HCT-15/FU colon cancer cells. (b) and (c) The cell migration assay of HCT-15 or HCT-15/FU cells treated with 0.76 mM 5-FU. (b) Transwell migration assay (scale bars, 50 μm) and (c) wound healing assay (scale bars, 200 μm). (d) The flow cytometric apoptosis assays of HCT-15 or HCT-15/FU cells treated with 0.76 mM 5-FU. The data represent the . Statistical significance: .
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