Research Article
Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy Targets
Table 2
Top ten SNVs and the corresponding neoantigens in the CRC cohort.
| | Chr | Location | Gene | AA change | Peptide | Frequency | HLA types |
| | chr12 | 25398284 | KRAS | G12D | VVVGADGVGK | 143 | A11:01 | | chr12 | 25398284 | KRAS | G12V | VVGAVGVGK | 104 | A11:01 | | chr3 | 1.79E+08 | PIK3CA | E545K | STRDPLSEITK | 63 | A03:01; A11:01 | | chr3 | 1.79E+08 | PIK3CA | E545K | ITKQEKDFLW | 63 | B57:01 | | chr3 | 1.79E+08 | PIK3CA | H1047R | ARHGGWTTK | 45 | B27:05 | | chr3 | 1.79E+08 | PIK3CA | R88Q | REEFFDETRQL | 30 | B40:01 | | chr2 | 70315174 | PCBP1 | L100Q | RPPVTQRLVV | 28 | B07:02 | | chr2 | 70315174 | PCBP1 | L100Q | SRPPVTQRL | 28 | C06:02; C07:01; C07:02 | | chr22 | 29091840 | CHEK2 | K373E | SEILGETSL | 21 | B18:01; B40:01 | | chr12 | 25398284 | KRAS | G12A | VVVGAAGVGK | 19 | A11:01 |
|
|
