Research Article

Bioinformatics Analysis of Key Genes and circRNA-miRNA-mRNA Regulatory Network in Gastric Cancer

Table 1

15 hub DEGs in the PPI networks.

Gene symbolOfficial full nameDegreeExpression in GC

FN1Fibronectin 164Upregulation
COL1A1Collagen type I alpha 1 chain45Upregulation
COL1A2Collagen type I alpha 2 chain42Upregulation
COL3A1Collagen type III alpha 1 chain41Upregulation
CD44CD44 molecule (Indian blood group)40Upregulation
SPARCSecreted protein acidic and cysteine rich36Upregulation
FBN1Fibrillin 136Upregulation
BGNBiglycan36Upregulation
UBE2CUbiquitin-conjugating enzyme E2 C35Upregulation
SPP1Secreted phosphoprotein 135Upregulation
TIMP1TIMP metallopeptidase inhibitor 135Upregulation
THBS1Thrombospondin 134Upregulation
COL5A2Collagen type I alpha 2 chain32Upregulation
CXCL8C-X-C motif chemokine ligand 831Upregulation
CCNB1Cyclin B131Upregulation