Research Article
CD44, IL-33, and ST2 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population
Table 3
Distribution and genotype frequencies of related polymorphisms in the HCC group and the control group.
| | Parameter | Case, (%) | Controls, (%) | OR (95% CI) | | ORadj (95% CI) | |
| | CD44 rs187115 | | | | | | | | All | | | | | | | | AA | 383 (67.8) | 421 (75.0) | 1.00 | | 1.00 | | | AG | 162 (28.7) | 131 (23.4) | 1.359 (1.039-1.778) | 0.025 | 1.359 (1.039-1.778) | 0.026 | | GG | 20 (3.5) | 9 (1.6) | 2.443 (1.099-5.430) | 0.028 | 2.469 (1.110-5.492) | 0.027 | | AG+GG | 182 (32.2) | 140 (25.0) | 1.429 (1.101-1.855) | 0.007 | 1.429 (1.102-1.854) | 0.007 | | Alleles | | | | | | | | A | 928 (82.1) | 973 (86.7) | 1.00 | | 1.00 | | | G | 202 (17.9) | 149 (13.3) | 1.421 (1.129-1.789) | 0.003 | 1.423 (1.131-1.792) | 0.003 | | IL-33 rs1929992 | | | | | | | | All | | | | | | | | AA | 169 (29.9) | 157 (28.0) | 1.00 | | 1.00 | | | GA | 261 (46.2) | 276 (49.2) | 0.879 (0.667-1.157) | 0.357 | 0.886 (0.672-1.168) | 0.390 | | GG | 135 (23.9) | 128 (22.8) | 0.980 (0.708-1.356) | 0.902 | 0.980 (0.708-1.358) | 0.906 | | AG+GG | 396 (70.1) | 404 (72.0) | 0.911 (0.704-1.178) | 0.476 | 0.916 (0.708-1.186) | 0.506 | | Alleles | | | | | | | | A | 599 (53.0) | 590 (52.6) | 1.00 | | 1.00 | | | G | 531 (47.0) | 532 (47.4) | 0.983 (0.833-1.160) | 0.840 | 0.984 (0.834-1.161) | 0.848 | | ST2 rs3821204 | | | | | | | | All | | | | | | | | GG | 198 (35.0) | 264 (47.1) | 1.00 | | 1.00 | | | CG | 255 (45.2) | 230 (41.0) | 1.478 (1.144-1.910) | 0.003 | 1.483 (1.147-1.916) | 0.003 | | CC | 112 (19.8) | 67 (11.9) | 2.229 (1.564-3.177) | ≤0.001 | 2.208 (1.548-3.149) | ≤0.001 | | CG+CC | 367 (65.0) | 297 (52.9) | 1.648 (1.297-2.093) | ≤0.001 | 1.647 (1.296-2.093) | ≤0.001 | | Alleles | | | | | | | | G | 631 (56.0) | 690 (61.5) | 1.00 | | 1.00 | | | C | 499 (43.0) | 432 (38.5) | 1.532 (1.290-1.820) | ≤0.001 | 1.527 (1.285-1.813) | ≤0.001 |
|
|
OR: odds ratio; ORadj: adjusted odds ratio; CI: confidence interval.
|
