Structure-Activity Relationship (SAR) and in vitro Predictions of Mutagenic and Carcinogenic Activities of Ixodicidal Ethyl-Carbamates

Table 3

Predictions of mutagenicity of ethyl-carbamates on different strains of Salmonella typhimurium with and without S9 metabolic activation.

CARBAMATE	Strain	With S9 activation	P-value	Without S9 activation	P-value
LQM 919	TA 97	Negative	p <0.001	Negative	p =0.100
	TA 98	Negative	p <0.001	Negative	p <0.05
	TA 102	Negative	p <0.01	Negative	p <0.01
	TA 1535	Negative	p <0.001	Negative	p <0.01
	TA 1537	Negative	p <0.001	Negative	p <0.05
	TA 1538	Negative	p <0.001	Negative	p <0.001
LQM 996	TA 97	Negative	p <0.001	Negative	p <0.001
	TA 98	Negative	p <0.001	Negative	p <0.01
	TA 102	Negative	p <0.01	Negative	p <0.001
	TA 1535	Negative	p <0.001	Negative	p <0.01
	TA 1537	Negative	p <0.001	Negative	p <0.01
	TA 1538	Negative	p <0.01	Negative	p <0.001

moderate confidence; strong confidence; very strong confidence.