Structure-Activity Relationship (SAR) and in vitro Predictions of Mutagenic and Carcinogenic Activities of Ixodicidal Ethyl-Carbamates
Table 4
Mutagenicity of carbamate LQM 919 towards Salmonella typhimurium TA98, TA100, TA1535, TA1537 and TA102 strain with or without S9 metabolic activation.
No. of his revertant colonies/plate (mean ± SD)
Concentration (mg/mL)
TA98
TA100
TA1535
TA1537
TA102
-S9
+S9
-S9
+S9
-S9
+S9
-S9
+S9
-S9
+S9
0 (-)
18.5 ± 3.2
27.7 ± 2.5
104.1 ± 10.8
120 ± 9
9.1 ± 3.9
16.5 ± 1.9
9.1 ± 3
14.6 ± 3
319.5 ± 75.7
330 ± 66
0.1
16.3 ± 4.9
31 ± 6.2
112 ± 20.7
133.3 ± 10.5
10 ± 1.7
13.6 ± 1.5
10.6 ± 2.5
14 ± 5.2
225 ± 26.5
347.6 ± 41.5
0.2
20.3 ± 4.1
28.7 ± 7.1
107.6 ± 15.8
118.6 ± 4.5
6 ± 3.4
9.3 ± 2.0
4.3 ± 0.5
9.6 ± 2
219.6 ± 5.8
265 ± 13
0.4
16.3 ± 2
30 ± 7.5
125.6 ± 19.4
89.6 ± 19.8
11 ± 2.6
11 ± 4.3
6.33 ± 3.2
9.3 ± 2
118.3 ± 21.9
250.3 ± 15.8
0.5
20.3 ± 4.5
32.3 ± 8.6
78 ± 2
106.3 ± 16.8
4 ± 3.4
12 ± 3
4 ± 2.6
9.6 ± 1.5
80.6 ± 2.8
101.6 ± 89.2
1
10 ± 5.2
25.6 ± 5.1
35 ± 22.9
28.3 ± 19.4
5 ± 1
6.6 ± 1.5
2 ± 2
6 ± 4.5
3.3 ± 5.7
0
Limit value:
37
55.4
208.2
240
18.2
33
18.2
29.2
639
660
Positive controls:
2-NF
2017 ± 460
Sodium azide
1666 ± 99
731 ± 77.2
Picrolonic acid
48.33 ± 25.1
4-NQO
1573 ± 61
2-AA
1831 ± 163
2277 ± 146
765 ± 45
441 ± 99
2050 ± 93
S9 = Microsomal fraction of liver of rats treated with phenobarbital and beta-naphthoflavone enriched with NADP and glucose-6-P; 2-NF =2-nitrofluorene; 4-NQO =4-nitroquinolido N-oxide; 2-AA =2-aminoanthracene.
