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BioMed Research International

BioMed Research International / 2020 / Article / Fig 5

Research Article

Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway

Figure 5

Western blot analysis of expression levels of the NF-κB signaling pathway in Hep3B and HepG2 liver cells. The protein expressions of p65, p-p65, IκBα, and p-IκBα in Hep3B and HepG2 liver cells measured by Western blotting. Results revealed that the expression levels of p-IκBα and p-p65 were decreased in HepG2 and Hep3B liver cancer cells treated with apatinib when compared with the control group in a dose-dependent manner. And the ratio of p-IκBα/IκBα and p-p65/p65 in cells was significantly lower compared with that of the control group. ImageJ software was used to analyze the gray values. indicates , .

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