Review Article

The Novel Coronavirus Disease (COVID-19): A PRISMA Systematic Review and Meta-Analysis of Clinical and Paraclinical Characteristics

Table 5

Meta-analysis of laboratory findings before removing Fan et al. study.

Group LAB testEffect size and 95% confidence intervalTest of null (2-tail)Heterogeneity
OutcomeNumber of studiesPoint estimateStandard errorVarianceLower limitUpper limit value value squared

CRP (mg/l)710.782.214.896.4415.114.870.000030.63
Lymphocytes (×109/l)71.000.130.020.731.267.480.000045.87
WBC (×109/l)74.870.260.074.365.3818.760.00000.00
ALT (U/l)523.432.848.0717.8629.008.250.00000.00
AST (U/l)525.842.476.0821.0130.6810.480.00001.71
Cr (μmol/l)569.903.8714.9762.3277.4818.060.00000.00
D-dimer (μg/l)5567.89112.1112568.89348.15787.625.070.00000.00
Hemoglobin (g/l)5131.713.3711.38125.10138.3239.050.00000.00
LDH (U/l)5258.5626.39696.51206.84310.299.800.000011.06
Neutrophils (×109/l)53.200.310.092.593.8010.380.00000.00
Platelets (×109/l)5166.3910.92119.17145.00187.7915.240.00000.00
Procalcitonin (ng/ml)50.170.080.010.010.322.150.031268.47
Creatine kinase (U/l)4110.1819.92396.7271.14149.225.530.00000.00
Total bilirubin (mmol/l)48.361.081.166.2510.487.760.00000.00
Albumin (g/l)338.611.462.1435.7541.4826.410.000044.52
BUN (mmol/l)34.830.550.303.755.918.770.00000.00
ESR240.7924.93621.75-8.0889.671.640.101891.15
Fibrinogen (g/l)23.210.220.052.783.6414.710.00000.00