Research Article
MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA
Figure 4
RPSA as a direct target of miR-587. (a) A total of 4884 overexpressed genes in HCC were screened out based on the TCGA database. (b) Thirteen potential target genes of miR-587 were included after intersecting outputs between TCGA database and TargetScan. (c) QRT-PCR assay revealed inverse expressions of RPSA and miR-587 in SMMC-7721 cells in both the mimic group () and the inhibitor group (). (d) The 3-UTR region of RPSA had two target sites interacting with miR-587. (e) Dual-luciferase reporter assay showed a specific interaction between miR-587 and the 3-UTR of RPSA mRNA (). , . miR: microRNA.
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