Development and Validation of a 34-Gene Inherited Cancer Predisposition Panel Using Next-Generation Sequencing

Table 1

Genes included in the 34-gene inherited cancer predisposition panel.

Gene name	Coding reference	Genomic reference
APC	NM_000038.5	NG_008481.4
ATM	NM_000051.3	NG_009830.1
BARD1	NM_000465.3	NG_012047.3
BMPR1A	NM_004329.2	NG_009362.1
BRCA1	NM_007294.3	NG_005905.2
BRCA2	NM_000059.3	NG_012772.3
BRIP1	NM_032043.2	NG_007409.2
CDH1	NM_004360.3	NG_008021.1
CDK4	NM_000075.3	NG_007484.2
CDKN2A	NM 000077.4	NG_007485.1
	NM_058195.3
CHEK2	NM_007194.3	NG_008150.2
EPCAM	NM_002354.2	NG_012352.2
MEN1	NM_130799.2	NG_008929.1
MLH1	NM_000249.3	NG_007109.2
MSH2	NM_000251.2	NG_007110.2
MSH6	NM_000179.2	NG_007111.1
MUTYH	NM_001128425.1	NG_008189.1
NBN	NM_002485.4	NG_008860.1
NF1	NM_000267.3	NG_009018.1
PALB2	NM_024675.3	NG_007406.1
PMS2	NM_000535.5	NG_008466.1
POLD1	NM_002691.3	NG_033800.1
POLE	NM_006231.3	NG_033840.1
PTEN	NM_000314.4	NG_007466.2
RAD51C	NM_058216.2	NG_023199.1
RAD51D	NM_002878.3	NG_031858.1
RET	NM_020975.4	NG_007489.1
SDHB	NM_003000.2	NG_012340.1
SDHC	NM_003001.3	NG_012767.1
SDHD	NM_003002.3	NG_012337.3
SMAD4	NM_005359.5	NG_013013.2
STK11	NM_000455.4	NG_007460.2
TP53	NM_000546.5	NG_017013.2
VHL	NM_000551.3	NG_008212.3