Research Article
Cognitive Protective Mechanism of Crocin Pretreatment in Rat Submitted to Acute High-Altitude Hypoxia Exposure
Figure 3
Crocin pretreatment improved the neuronal morphology of the hippocampus in rats under acute high-altitude hypoxia (, ×400 magnification, scale bar: 50 μm). Ctr: control group, with saline. AHH: rats exposed under hypoxia for 3 days at 4200 m. LHG, MHG, HHG: rats exposed under hypoxia for 3 days at 4200 m after pretreatment by 25 mg/kg/d, 50 mg/kg/d, and 100 mg/kg/d of crocin. (a) HE-stained sections across the hippocampal CA1 region. (b, c) Nissl-stained sections across the hippocampal CA1 region. (↑ neurons shrunk and nuclear pyknosis). # versus Ctr, versus AHH, ■ versus Ctr, △ versus HLG, and ▲ versus HMG.
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