A Pipeline to Call Multilevel Expression Changes between Cancer and Normal Tissues and Its Applications in Repurposing Drugs Effective for Gastric Cancer

Table 2

Evidence of drugs for gastric cancer.

Drug	Possible effects	Evidence (DOI)
Oxaliplatin	An alkylating agent that inhibits DNA replication by forming adducts between two adjacent guanines or guanine and adenine molecules	10.1007/s00280-007-0515-7
		10.1186/1756-9966-29-118
		10.1016/S0140-6736(11)61873-4
6-Alpha-methylprednisolone	Strong anti-inflammatory effect	10.1002/ddr.430020113
		10.1111/nmo.12391
Valproic acid	Inhibits tumor growth by inducing apoptosis	10.2147/DDDT.S110425
		10.3969/j.issn.1000-4718.2012.10.023
		10.1371/journal.pone.0018562
Lactam	Inhibits human gastric cancer proliferation and induces apoptosis	10.1021/ic400019r
		10.3390/molecules 18077436
Retinoic acid	Inhibit cell cycle progression	10.1046/j.1432-0436.2001.068001013.x
		10.1242/jcs.01474
		10.1111/j.1440-1746.2004.03336.x
		10.1046/j.1432-0436.1997.6150313.x
Dexamethasone	Dexamethasone not only suppressed the apoptosis-associated up-regulation of Bcl-xS but also enhanced the basal level of Bcl-xL in the cells; significantly reduces the affinity of tumor necrosis factor for gastric cancer cells	10.1016/S0014-5793(97)01083-1
		CNKI:SUN:YYDB.0.2005-07-018
		10.1007/s00464-014-3463-4
Curcumin	Inhibits proliferation of several cancer cell lines	10.4161/cbt.8.14.8720
		10.1016/j.phymed.2012.12.007
		10.3892/or.2011.1410
		10.1155/2012/915380

The drugs obtained are rigorously screened and their mechanisms discovered through the relevant literature.