Molecular Mechanism of HSF1-Upregulated ALDH2 by PKC in Ameliorating Pressure Overload-Induced Heart Failure in Mice

Figure 1

TAC pressure overload model, the expression of HSF1, ALDH2, and mouse cardiac remodeling and heart function after TAC 4 weeks. (a) Mouse TAC pressure overload model: mouse aortic constriction (the red arrow shows mouse aortic constriction ring measured by echocardiography) and common carotid artery pressure (measured by Millar micromanometer). (b) The relative mRNA level of the mouse heart tissue (sham and TAC wild-type mice). (c) The relative protein level of the mouse heart tissue (sham and TAC wild-type mice). (d) Mouse heart histologic section: HE (1.25x) and Masson (5.0x) staining and echocardiography measure (sham: sham-operated mice; WT: wild-type mice; HSF1 TG: HSF1 transgene mice; HSF1 KO: HSF1 knockout mice). LVW/BW: left ventricular weight/body weight; LVID, d: left ventricular internal dimension, diastolic; LVEF: left ventricular ejection fraction. , vs. sham, ^#, ^## vs. WT TAC, .

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