Pharmacogenetic Association between XRCC1 Polymorphisms and Response to Platinum-Based Chemotherapy in Asian Patients with NSCLC: A Meta-Analysis

Table 1

Basic characteristics of all included studies.

Author	Year	Country	Tumor stage	Sample size (male/female)	Median age (year)	Smoking rate (%)	Genotyping method	SNPs	Clinical outcomes	NOS
Sun	2009	China	IV	82 (53/29)	59	NR	DNA microarray	rs25487, rs1799782	ORR	6
Yao	2009	China	IIIB-IV	108 (71/38)	61	NR	PCR-RFLP	rs25487	ORR, OS	6
Yuan	2010	China	III-IV	199 (129/70)	56	59.3	PCR-RFLP	rs25487, rs1799782	OS, PFS	7
Shiraishi	2010	Japan	III-IV	201 (136/65)	57.2	63.2	TaqMan	rs25487	ORR	6
Li	2011	China	III-IV	89 (64/25)	59.1	NR	PCR-RFLP	rs25487	ORR	7
Zhou	2011	China	IV	111 (67/44)	57	NR	Direct sequencing	rs25487	ORR	7
Liao	2012	China	IIIB-IV	62 (35/27)	57	NR	SNPstream	rs25487	ORR, OS	6
Ke	2012	China	I-IV	460 (334/126)	59.5	67.4	PCR-CTTP	rs25487, rs1799782	OS	6
Zhao	2013	China	IIIB-IV	147 (92/55)	60	45.9	TaqMan	rs25487, rs1799782	ORR, OS, PFS	7
Lee	2013	South Korea	III-IV	382 (311/71)	NR	83.2	MALDI-TOF	rs25487	ORR, OS	6
Zhang	2014	China	III-IV	375 (249/126)	60.9	NR	MALDI-TOF	rs25487, rs1799782	ORR, OS, PFS	6
Peng	2014	China	III-IV	235 (180/55)	58	61.3	PCR-CTTP	rs25487	ORR	6
Liu	2014	China	I-IV	378 (297/81)	62.4	56.1	MALDI-TOF	rs25487, rs1799782	ORR, OS, PFS	7
Du	2014	China	III-IV	161 (108/53)	60	54.7	qPCR	rs25487	ORR	7
Deng	2015	China	IIIB-IV	97 (66/31)	57	40.2	Direct sequencing	rs25487	ORR, PFS	6
Han	2015	China	IIIB-IV	325 (116/209)	57.6	68.3	PCR-RFLP	rs25487, rs1799782	ORR, OS	7
Liu	2015	China	IIIB-IV	322 (226/96)	62.5	43.5	PCR-RFLP	rs25487, rs1799782	ORR, OS	6
Zhao	2015	China	III-IV	206 (124/82)	56.1	65.5	PCR-RFLP	rs25487, rs1799782	ORR, OS	7
Chen	2016	China	III-IV	1024 (724/300)	NR	55.6	MALDI-TOF	rs25487	ORR	6
Bu	2016	China	III-IV	141 (100/41)	55.9	66.0	PCR-RFLP	rs25487, rs1799782	ORR, OS	6
Liu	2016	China	IIIB-IV	252 (104/148)	56.3	75.4	PCR-RFLP	rs25487, rs1799782	ORR, OS	7
Liao	2018	China	IV	58 (39/19)	58	44.8	TaqMan	rs25487	ORR, OS	7
Dong	2018	China	IIIB-IV	152 (101/51)	52	52.0	MALDI-TOF	rs25487	ORR	6

PCR-RFLP: polymerase chain reaction restriction fragment length polymorphism; PCR-CTTP: PCR with the confronting-two-pair primer; MALDI-TOF: matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; ORR: objective response rate; OS: overall survival; PFS: progression-free survival; NR: not reported. NOS: Newcastle-Ottawa Scale.