Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma

Table 4

The correlation between MCMs and survival outcomes in hepatic carcinoma based upon the alcohol consumption and hepatitis virus status.

Gene	Survival outcome	Alcohol consumption -		Alcohol consumption +		Hepatitis virus -		Hepatitis virus +
		HR	value	HR	value	HR	value	HR	value
MCM2	OS	2.43	0.00022	2.09	0.0578	3.37	0.00001	1.73	0.1849
	RFS	2	0.0018	2.25	0.012	3.17	0.0000054	1.33	0.2661
	PFS	1.85	0.0024	2.37	0.0031	2.67	0.000022	1.45	0.1802
	DSS	3.4	0.000043	1.77	0.1096	3.25	0.000032	2.55	0.0326
MCM3	OS	1.87	0.0153	1.77	0.0696	2.69	0.000055	1.52	0.2548
	RFS	2.1	0.0012	2.18	0.0447	2.37	0.0007	1.85	0.0272
	PFS	2.28	0.0004	1.77	0.0412	2.53	0.000024	1.8	0.028
	DSS	3.66	0.0009	1.78	0.1115	4.07	0.000011	2.76	0.0547
MCM4	OS	2.34	0.0004	1.51	0.203	3.09	0.0000021	1.52	0.2329
	RFS	1.3	0.2924	2.25	0.014	3.32	0.0000053	0.64	0.1563
	PFS	1.43	0.1033	1.87	0.0168	3.12	0.00000047	0.75	0.2438
	DSS	3.22	0.0002	2.43	0.0126	5.01	0.000000011	2.9	0.0721
MCM5	OS	1.74	0.0208	2.59	0.0028	2.3	0.0004	1.87	0.0582
	RFS	1.9	0.0047	2.48	0.0024	2.94	0.000017	1.32	0.2703
	PFS	1.74	0.0078	2.22	0.002	2.57	0.000018	1.3	0.2851
	DSS	2.56	0.0019	2.78	0.005	2.79	0.0002	2.32	0.0392
MCM6	OS	2.7	0.000019	1.66	0.1114	2.86	0.0000058	2.04	0.0316
	RFS	2.37	0.0002	2.24	0.0074	3.37	0.0000019	1.74	0.0258
	PFS	2.44	0.00002	2.41	0.001	3.48	0.000000019	1.7	0.0218
	DSS	4.28	0.00000063	1.93	0.067	4.5	0.00000013	2.26	0.0469
MCM7	OS	2.13	0.0019	2.56	0.029	3.07	0.0627	1.75	0.0889
	RFS	1.92	0.0035	3.21	0.0059	3.02	0.000038	1.41	0.2594
	PFS	1.95	0.0035	3.06	0.0014	2.99	0.0000035	1.59	0.1061
	DSS	3.62	0.0003	2.44	0.0627	3.95	0.00001	1.93	0.2238

values ≤ 0.05 were considered statistically significant.