Identification and Validation of an Energy Metabolism-Related lncRNA-mRNA Signature for Lower-Grade Glioma
Table 3
Univariate and multivariate Cox regression analyses of clinical pathologic features for overall survival.
Variables
TCGA ()
Univariate analysis
Multivariate analysis
HR
95% CI
value
HR
95% CI
value
Age (years, )
1.057
1.043-1.072
1.049
1.003-1.096
Gender (male/female)
286/234
1.145
0.811-1.617
—
—
—
Animal insect allergy history (yes/no/-)
16/289/215
0.831
0.202-3.428
—
—
—
Asthma history (yes/no/-)
22/346/152
0.894
0.409-1.956
—
—
—
Food allergy history (yes/no/-)
20/290/210
1.008
0.363-2.801
—
—
—
Hay fever history (yes/no/-)
38/304/178
0.488
0.177-1.347
—
—
—
Headache history (yes/no/-)
174/297/49
0.841
0.576-1.227
—
—
—
Histological type (astrocytoma/oligoastrocytoma/oligodendroglioma)
194/132/194
0.756
0.620-0.921
0.529
0.244-1.149
IDH1 mutation (yes/no/-)
91/34/395
0.181
0.0675-0.484
0.226
0.0729-0.701
Neoplasm histologic grade (G2/G3/-)
254/265/1
3.416
2.341-4.985
0.949
0.294-3.063
Radiation therapy (yes/no/-)
294/181/45
1.847
1.209-2.820
1.981
0.584-6.722
Targeted molecular therapy
268/200/52
1.389
0.955-2.019
—
—
—
Risk score (high/low)
260/260
3.192
2.182 -4.670
5.041
1.272-19.97
Death (dead/alive)
133/387
—
—
—
—
—
—
Overall survival days (months, )
—
—
—
—
—
—
HR: hazard ratio; CI: confidence interval; SD: standard deviation; IDH: isocitrate dehydrogenase; TCGA: The Cancer Genome Atlas. Bold indicated the factors with statistical difference ().
