Cerebrospinal Fluid Cytokines in Patients with Neurosyphilis: The Significance of Interleukin-10 for the Disease

Table 2

CSF biomarker levels of patients with ANS, SNS, and NNS.

	NS ()		NNS ()
	SNS ()	ANS ()
IL-1β (pg/mL)	0.10 (0.09-0.12)	0.10 (0.09-0.12)	0.11 (0.10-0.12)
IL-4 (pg/mL)	1.05 (0.90-1.89)	1.05 (0.90-1.42)	1.29 (0.94-2.07)
IL-6 (pg/mL)	1.16 (0.49-2.21)	0.75 (0.41-2.09)	0.52 (0.45-1.01)
IL-10 (pg/mL)	0.95 (0.70-1.66)^a,b	0.68 (0.55-0.96)^c	0.47 (0.44-0.50)
IL-21 (pg/mL)	0.42 (0.35-0.43)	0.38 (0.31-0.46)	0.41 (0.37-0.47)
TNF-α (pg/mL)	0.54 (0.47-0.75)	0.54 (0.43-0.70)	0.61 (0.51-0.63)
sTREM2 (ng/mL)	65.01 (43.59-86.25)^a,b	39.63 (28.00-55.07)^c	28.75 (20.19-35.33)
NFL (pg/mL)	64.08 (40.01-146.82)^a,b	33.79 (13.92-49.44)^c	5.71 (0.18-35.23)

Values are expressed as median (IQR). NS: neurosyphilis; ANS: asymptomatic neurosyphilis; SNS: symptomatic neurosyphilis; NNS: nonneurosyphilis; IL: interleukin; TNF: tumor necrosis factor; sTREM2: soluble triggering receptor expressed on myeloid cells 2; NFL: neurofilament light protein. ^a compared with ANS. ^b compared with NNS. ^c compared with NNS.