Potential Anticancer Activity of Crude Ethanol, Ethyl Acetate, and Water Extracts of Ephedra foeminea on Human Osteosarcoma U2OS Cell Viability and Migration

Table 2

mRNA steady-state gene expression for markers involved in cell proliferation, apoptosis, and migration shown as fold change relative to that observed in untreated cells.

Gene	EtOH		H2O		EtOAc
	Fold change	value	Fold change	value	Fold change	value
Twist-1	-19.360	<0.001	-4.870	<0.001	-6.33	<0.001
p53	-16.038	<0.001	-4.166	<0.001	-1.857	0.035
MMP2	-14.657	<0.001	-4.383	<0.001	-1.994	0.131
MMP1	-7.177	<0.001	-3.658	<0.001	-1.181	0.220
BAX	-6.471	<0.001	-4.172	<0.001	-3.011	0.027
N-cadherin	-6.329	<0.001	-2.966	0.001	-1.181	0.220
B-catenin	-5.601	<0.001	-4.503	<0.001	-1.533	0.299
RUNX2	-5.211	<0.001	-2.993	0.001	-1.918	0.166
Vimentin	-4.189	<0.001	-3.265	0.001	—	—