Potential Anticancer Activity of Crude Ethanol, Ethyl Acetate, and Water Extracts of Ephedra foeminea on Human Osteosarcoma U2OS Cell Viability and Migration

Table 3

Comparison of U2OS gene expression when treated with either E. foeminea, doxorubicin, or nutlin-3.

Treatment	Downregulated genes		Upregulated genes
E. foeminea∩doxorubicin∩nutlin-3	RUNX2	—	—	—
E. foeminea∩doxorubicin	B-catenin	N-cadherin	—	—
E. foeminea∩nutlin-3	Twist-1	—	—	—
E. foeminea	MMP2	BAX	—	—
	TP53	MMP1	—	—
	Vimentin	—	—	—
Doxorubicin∩nutlin-3	DCHS2	BIRC5	FAT3	BAX
	FAT4	CDH12	PIDD1	CDH10
	SOX2	CDH18	TP53I11	CDH22
	—	—	TP53I3	CDIP1
	—	—	TP53INP1
Doxorubicin	XIAP	CBY1	LOC100653137///CDH23	CDH9
	CPED1	CDH4	MIR6513///TMBIM1	CDHR1
	CTNNA1	CELSR3	TMBIM6	CDHR3
	CTNND2	CPED1	TP53AIP1	CELSR1
	FAT1	TP53BP1	TP53I13	CELSR2
	FAT3	JMY	TP53INP2	CTNNB1
	TMBIM4	—	Twist-1	DACT1
	TMX2-CTNND1///CTNND1	—	TWIST2	DACT3
Nutlin-3	CELSR2	CDH24	CBY1	JMY
	DACT1	CDH6	CDH11	LINC-PINT
	DCHS1	CDHR2	CDH13	TWISTNB
	LOC100653137///CDH23	—	CDH15	XIAP
	—	—	CDH16	—