Research Article

Protective Effect of Methylxanthine Fractions Isolated from Bancha Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats

Table 3

Effects of Bancha methylxanthine administration at doses of 5 mg/kg and 1 mg/kg on CK, CK-MB, LDH, and AST enzyme activities in doxorubicin-induced cardiotoxicity (cumulative dose: 20 mg/kg).

GroupsCreatinine kinase (CK) (U/L)Creatinine kinase MB fraction (CK-MB) (U/L)Lactate dehydrogenase (LDH) (U/L)Aspartate aminotransferase (AST) (U/L)

Group 1: control
Group 2: 5 mg/kg (p.o.) MXB
Group 3: 1 mg/kg (p.o.) MXB
Group 4: 5 mg/kg (p.o.) MXB+doxo 20 mg/kg (i.p.)
Group 5: 1 mg/kg (p.o.) MXB+doxo 20 mg/kg (i.p.)
Group 6: doxo 20 mg/kg (i.p.)