Protective Effect of Methylxanthine Fractions Isolated from Bancha Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats

Table 4

Effects of Bancha methylxanthine administration at doses of 5 mg/kg and 1 mg/kg on serum levels of urea, creatinine, and uric acid in doxorubicin-induced nephrotoxicity (cumulative dose: 20 mg/kg).

Groups	Urea (BUN) (mmol/L)	Creatinine (μmol/L)	Uric acid (μmol/L)
Group 1: control
Group 2: 5 mg/kg (p.o.) MXB
Group 3: 1 mg/kg (p.o.) MXB
Group 4: 5 mg/kg (p.o.) MXB+doxo 20 mg/kg (i.p.)
Group 5: 1 mg/kg (p.o.) MXB+doxo 20 mg/kg (i.p.)
Group 6: doxo 20 mg/kg (i.p.)