Pulsed Electromagnetic Field Inhibits Synovitis via Enhancing the Efferocytosis of Macrophages

Figure 6

PEMF exerts anti-inflammatory effect through the P38/TNF-α/efferocytosis pathway. After treatment with PEMF, the phosphorylation of P38 is decreased, which decreases the transcription of TNF-α via affecting the downstream transcription factors. TNF-α is one of the cytokines that can inhibit efferocytosis and thus affect the resolution of inflammation. The PEMF reduces the production of TNF-α by inhibiting the phosphorylation of P38, thereby enhancing efferocytosis and promoting inflammation resolution.