Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity
Table 1
Demographics and clinical data of hospitalized children with single HAdV-3 or single HAdV-7 infection.
Characteristic
All patients ()
HAdV-3 ()
HAdV-7 ()
Male sex
25 (69.4)
29 (78.4)
0.463
Median age, month (range)
33.1 (6.7-92.5)
25.2 (3.2-111)
0.201
Fever duration days (range)
6.6 (1-21)
11.1 (2-34)
0.002
Median peak temperature, °C
0.796
Respiratory symptoms
Cough
29 (80.6)
32 (86.5)
0.494
Rhinorrhea
11 (30.6)
7 (18.9)
0.249
Tachypnea/dyspnea
10 (27.8)
21 (72.4)
0.012
Pleural effusion
1 (2.8)
16 (43.2)
<0.001
Rales
19 (52.8)
31 (83.8)
0.004
Laboratory tests
WBC, ×109 cells/l
<0.001
> cells/l
12 (33.3)
5 (13.5)
0.045
CRP, mg/l (IQR)
32.8 (54.7–5.1)
34.6 (59.6–8.1)
0.839
>0.15 mg/l
35 (97.2)
37 (100)
0.307
>40 mg/l
10 (27.8)
11 (29.7)
0.854
PCT, ng/ml (IQR)
0.74 (0.70-0.11)
3.34 (3.95–0.34)
<0.001
>0.05 ng/ml
32 (88.9)
36 (97.3)
0.199
>0.5 ng/ml
10 (27.8)
27 (72.9)
<0.001
Outcomes
Hospitalized duration days (range)
10.7 (3-44)
17.7 (3-84)
0.01
Intensive care required
19 (52.8)
23 (62.2)
0.417
Mechanical ventilation
4 (11.1)
11 (29.7)
0.049
Death
None
4 (10.8)
<0.001
Values are no. (%) of patients or , unless otherwise indicated. Range: extreme values at both ends; IQR: interquartile range; WBC: whole blood cell; CRP: C-reactive protein; PCT: procalcitonin.
