Preclinical Development of Mahanine-Enriched Fraction from Indian Spice Murraya koenigii for the Management of Cancer: Efficacy, Temperature/pH stability, Pharmacokinetics, Acute and Chronic Toxicity (14-180 Days) Studies

Figure 5

Histopathology of different organs from mice of acute, subchronic, and chronic toxicity studies. (a) Organs from control and 5000 mg/kg MEF_M2-fed mice were isolated. These are sectioned and stained with Haemotoxylin and Eosin (H&E) for histopathological observation as discussed in Methods. (b) Histopathology of different organs collected from 14-day-fed mice. (c) Histopathology of different organs collected from 90-day-fed mice (sub-chronic toxicity study). (d) 180-day-fed mice (chronic toxicity study) were similarly stained for histopathology study. No significant changes or damages were observed in tissues of MEF_M2-fed mice compared to the control groups. All are representative images from a single mouse from each group. Magnification (20x) and scale bar are shown in all the images.

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