Preclinical Development of Mahanine-Enriched Fraction from Indian Spice Murraya koenigii for the Management of Cancer: Efficacy, Temperature/pH stability, Pharmacokinetics, Acute and Chronic Toxicity (14-180 Days) Studies

Table 11

Serum biochemistry of mice in the subchronic toxicity study.

Test (units)	Female		Fold change	Male		Fold change
	Control	Treated		Control	Treated
Urea (mg/dL)			1.09			1.15
BUN (mg/dL)			1.09			1.15
Creatinine (mg/dL)			1.1			1.08
ALT (U/L)			1.3			0.87
ALP (U/L)			1.5			0.6
GGT (U/L)			0.75			0.7
Bilirubin (mg/dL)			0.98			1.14
Total cholesterol (mg/dL)			1.03			0.93
Triglycerides (mg/dL)			1.4			1.06
SGOT (U/L)			0.9			0.8
Total protein (g/dL)			1			0.92
Albumin (ALB, g/dL)			1			0.93
Globulin; (GLB, g/dL)			1			0.91
ALB : GLB			1			1
LDH (U/L)			0.97			1.3

Data indicate . There are no significant () differences between the control and treated mice in their tested biochemical parameters.