Preclinical Development of Mahanine-Enriched Fraction from Indian Spice Murraya koenigii for the Management of Cancer: Efficacy, Temperature/pH stability, Pharmacokinetics, Acute and Chronic Toxicity (14-180 Days) Studies

Table 12

Serum biochemistry of treated/control mice in the chronic toxicity study.

Test (units)	Female		Fold change	Male		Fold change
	Control	Treated		Control	Treated
Urea (mg/dL)			0.92			1.05
BUN (mg/dL)			0.91			1.05
Creatinine (mg/dL)			0.93			1.04
ALT (U/L)			0.85			0.73
ALP (U/L)			0.94			0.87
GGT (U/L)			0.82			1.28
Bilirubin (mg/dL)			0.91			1.15
Total cholesterol (mg/dL)			1.02			1.22
Triglycerides (mg/dL)			0.68			0.87
SGOT (U/L)			1.0			1.18
Total protein (g/dL)			0.94			0.98
Albumin (ALB, g/dL)			0.95			0.99
Globulin (GLB, g/dL)			0.92			0.97
ALB : GLB			1.01			1.02
LDH (U/L)			0.93			0.98

Data indicate . There are no significant () differences between the control and treated mice in their biochemical parameters.