Preclinical Development of Mahanine-Enriched Fraction from Indian Spice Murraya koenigii for the Management of Cancer: Efficacy, Temperature/pH stability, Pharmacokinetics, Acute and Chronic Toxicity (14-180 Days) Studies

Table 4

pH stability of MEF_M2.

	Exposure of MEFM2 at different pH	Relative % of mahanine after		IC50 (μg/mL) of MEFM2 after 3 h exposure against PA1 cells
		2 h	3 h
Freshly prepared MEFM2	—	100	100
	pH 1.0	99.2	91.4
	pH 5.0	100	96
	pH 7.2	100	100
	pH 10	100	98.7

This data was derived from three individual experiments, and the is indicated.