Icariin Ameliorates Lower Back Pain in Rats via Suppressing the Secretion of Cytokine-Induced Neutrophil Chemoatractant-1

Figure 2

ICA treatment alleviated discogenic LBP. (a) Seven days after puncture, the animals showed obvious LBP; however, administration of ICA significantly alleviated the LBP at a dosage of 50 mg/kg/d or 100 mg/kg/d. (b) The analgesic effect of ICA treatment was similar to that of celecoxib, and the effect of ICA was more long-lasting (<0.001 on comparison between the sham-surgery group and the puncture+saline group. ⁺<0.05, ⁺⁺<0.01, and ⁺⁺⁺<0.001 on comparison between the puncture+saline group and the puncture+ICA 50 mg/kg group. ^###<0.001 indicated the comparison between the puncture+saline group and the puncture+ICA 100 mg/kg. ^&<0.05 and ^&&&<0.001 on comparison between the puncture+ICA 50 mg/kg group and the puncture+ICA 100 mg/kg group. ^×<0.05, ^××<0.01, and ^×××<0.001 when compared between the puncture+ICA 100 mg/kg group and the puncture+celecoxib group. The data are shown as . for each group. Two-way ANOVA and Tukey’s multiple comparison test were used for statistical analysis).

(a)

(b)