BioMed Research International / 2020 / Article / Tab 3 / Review Article
Space Radiation Biology for “Living in Space” Table 3 Biological effects of radiation and simulated μG in ground experiments.
Interactive effects Cells Biological index Devices Irradiationa Ref. Yes, ↑ Lymphoblastoid Mutation, micronuclei RWV Pre-60 Co, γ -rays [183 ] Lymphocyte Mutation RWV Pre-60 Co, γ -rays [184 ] Lymphocyte γ -H2AXRWV Pre-137 Cs, γ -rays [185 ] Lymphoblast Apoptosis, ROS RWV Post-C-ion [186 ] Fibroblast Gene induction RPM + 252 Cf, neutron [189 ] Neuron Apoptosis, gene induction RPM + 252 Cf, neutron [190 ] Fibroblast Chromosomal aberration SSS + X-rays, + C-ion [193 ] Fibroblast Cell cycle-promoting genes SSS + C-ion [194 ] Yes, ↓ Lymphocyte Apoptosis RWV Pre-137 Cs, γ -rays [187 ] Lymphoblastoid Apoptosis RWV Pre-60 Co, γ -rays [183 ] Lymphocyte Micro-RNA RWV Pre-137 Cs, γ -rays [188 ] Fibroblast Cell cycle-suppressing genes SSS + C-ion [194 ]
ROS: reactive oxygen species; RWV: rotating wall vessel bioreactor; RPM: random positioning machine; SSS: system of simultaneous irradiation in simulated-microgravity. a + means simultaneous irradiation with spaceflight.