TY - JOUR A2 - Papini, Roberto Amerigo AU - Khue, Pham Minh AU - Thuy Linh, Nguyen Thi AU - Vinh, Vu Hai AU - Dung, Luu Vu AU - Nguyen Van, Bang PY - 2020 DA - 2020/08/20 TI - Hepatitis B Infection and Mother-to-Child Transmission in Haiphong, Vietnam: A Cohort Study with Implications for Interventions SP - 4747965 VL - 2020 AB - Background. There is little data available on HBV infection and mother-to-child transmission (MTCT) in Vietnam. Objective. This study is aimed at assessing the prevalence of HBV infection and the current situation of MTCT in Haiphong, Vietnam. Methods. A transversal survey of 1721 pregnant women followed by an observational prospective cohort study of 183 HBV-infected women was conducted at Haiphong Gyneco-Obstetric Hospital. Women were followed up up to 12-month postpartum; use of prevention measures and the MTCT rate were evaluated. HBV infection in children was defined by a HBsAg-positive test at 12 months of age. Results. At baseline, 183 of 1721 pregnant women (10.6%) tested HBsAg positive. Among them, 23.0% were HBeAg positive, 26.2% had a detectable load of HBV DNA, and 13.1% had a HBV DNA load200,000 IU/mL. All women underwent MTCT prevention antiviral therapy. At delivery, 98.9% of newborns receive a HBV vaccine birth dose, and 82% received HBIG. At 12 months of age, 94.7% have received the scheduled HBV vaccines. Eight percent of infants born from followed-up women were HBsAg positive. The mother’s HBeAg-positive status was associated with a higher risk of HBV infection in infants. Conclusion. The HBV prevalence and MTCT rates are high in Haiphong. A strong national plan to increase the access to preventive measures and to monitor results is needed in order to decrease this prevalence. SN - 2314-6133 UR - https://doi.org/10.1155/2020/4747965 DO - 10.1155/2020/4747965 JF - BioMed Research International PB - Hindawi KW - ER -