Research Article

Systems Pharmacology-Based Research on the Mechanism of Tusizi-Sangjisheng Herb Pair in the Treatment of Threatened Abortion

Table 2

The information of related targets of the Tusizi-Sangjisheng herb pair.

No.Target nameGene nameUniProt ID

126S proteasome non-ATPase regulatory subunit 3PSMD10O75832
272 kDa type IV collagenaseMMP2P08253
378 kDa glucose-regulated proteinHSPA5P11021
4AcetylcholinesteraseACHEP22303
5Activator of 90 kDa heat shock protein ATPase homolog 1AHSA1O95433
6Androgen receptorNCOA4Q13772
7Apoptosis regulator BAXBAXQ07812
8Arachidonate 5-lipoxygenaseALOX5P09917
9ATP-binding cassette subfamily G member 2ABCG5Q9H222
10Baculoviral IAP repeat-containing protein 5BIRC5O15392
11Bcl-2-like protein 1BCL2L1Q07817
12Beta-2 adrenergic receptorADRB2P07550
13Caspase-8CASP8Q14790
14Cathepsin DCTSDP07339
15Caveolin-1CAV1Q03135
16CD40 ligandCD40LGP29965
17Cellular tumor antigen p53TP53P04637
18Claudin-4CLDN4O14493
19Coagulation factor VIIF7P08709
20C-reactive proteinCRPP02741
21C-X-C motif chemokine 10CXCL10P02778
22C-X-C motif chemokine 11CXCL11O14625
23C-X-C motif chemokine 2CXCL2P19875
24Cyclin-dependent kinase inhibitor 1CDKN1BP46527
25Cytochrome P450 1A1CYP1A1P04798
26Cytochrome P450 1B1CYP1B1Q16678
27Cytochrome P450 3A4CYP3A4P08684
28DDB1- and CUL4-associated factor 5DCAF5Q96JK2
29Dipeptidyl peptidase IVDPP4P27487
30DNA topoisomerase 1TOP1P11387
31E-selectinSELEP16581
32Estrogen sulfotransferaseSULT1E1P49888
33ETS domain-containing protein Elk-1ELK1P19419
34G1/S-specific cyclin-D1CCND1P24385
35G2/mitotic-specific cyclin-B1CCNB1P14635
36Gamma-aminobutyric acid receptor subunit alpha-1GABRA1P14867
37Glutathione S-transferase Mu 1GSTM1P09488
38Heat shock factor protein 1HSF1Q00613
39Heme oxygenase 1HMOX1P09601
40Inhibitor of nuclear factor kappa-B kinase subunit alphaCHUKO15111
41Insulin receptorINSRP06213
42Interleukin-1 alphaIL1AP01583
43Interleukin-1 betaIL1BP01584
44Interleukin-10IL10P22301
45Interleukin-2IL2P60568
46Interleukin-6IL6P05231
47Interleukin-8CXCL8P10145
48Interstitial collagenaseMMP1P03956
49Mitogen-activated protein kinase 1Mapk1P63085
50mRNA of PKA catalytic subunit C-alphaPRKACAP17612
51Myc protooncogene proteinMYCP01106
52MyeloperoxidaseMPOP05164
53Neutrophil cytosol factor 1NCF1P14598
54Nuclear factor erythroid 2-related factor 2NFE2L2Q16236
55Nuclear receptor coactivator 2NCOA2Q15596
56Peroxisome proliferator-activated receptor alphaPPARAQ07869
57Peroxisome proliferator activated receptor deltaPPARDQ03181
58Peroxisome proliferator activated receptor gammaPPARGP37231
59Plasminogen activator inhibitor 1SERPINE1P05121
60Poly [ADP-ribose] polymerase 1TNKSO95271
61Potassium voltage-gated channel subfamily H member 2KCNH2Q12809
62Prostaglandin G/H synthase 1PTGS1P23219
63Protooncogene c-FosFOSP01100
64Puromycin-sensitive aminopeptidaseNPEPPSP55786
65RAC-alpha serine/threonine-protein kinaseAKT1P31749
66RAF protooncogene serine/threonine-protein kinaseRAF1P04049
67Ras association domain-containing protein 1RASSF1Q9NS23
68Ras GTPase-activating protein 1RASA1P20936
69Receptor tyrosine-protein kinase erbB-2ERBB2P04626
70Receptor tyrosine-protein kinase erbB-3ERBB3P21860
71Retinoic acid receptor RXR-alphaRXRAP19793
72Runt-related transcription factor 2RUNX2Q13950
73Serine/threonine-protein kinase Chk2CHEK2O96017
74Serum paraoxonase/arylesterase 1PON1P27169
75Sodium channel protein type 5 subunit alphaSCN5AQ14524
76Solute carrier family 2, facilitated glucose transporter member 4SLC2A4P14672
77Stromelysin-1MMP3P08254
78ThrombinF2P00734
79ThrombomodulinTHBDP07204
80Transcription factor AP-1JUNP05412
81Transcription factor E2F1E2F1Q01094
82Transcription factor E2F2E2F2Q14209
83Transcription factor p65RELAQ04206
84Trypsin-1PRSS1P07477
85Type I iodothyronine deiodinaseDIO1P49895
86Xanthine dehydrogenase/oxidaseXDHP47989
872,4-Dienoyl-CoA reductase, mitochondrialDECR1Q16698
88Acetyl-CoA carboxylase 1ACACAQ13085
89ATP-citrate synthaseACLYP53396
90Coagulation factor XaF10P00742
91Cytochrome P450 2B6CYP2B6P20813
92Endothelin-converting enzyme 1ECE1P42892
93Glucose-6-phosphate 1-dehydrogenaseG6PDP11413
94NADPH oxidase 1NOX1Q9Y5S8
95NADPH oxidase 3NOX3Q9HBY0
96Nitric oxide synthase, endothelialNOS3P29474
97Peroxisomal acyl-coenzyme A oxidase 1ACOX1Q15067
98Peroxisomal bifunctional enzymeEHHADHQ08426
99Sterol regulatory element-binding protein 1SREBF1P36956
100Aldose reductaseAKR1B10O60218
101Amine oxidase [flavin-containing] BMAOBP27338
102Cyclin-A2CCNA2P20248
103Estrogen receptor betaESRRBO95718
104Glutamate receptor 2GRIA2P42262
105Mitogen-activated protein kinase 14MAPK14Q16539
106Nitric oxide synthase, inducibleNOS2P35228
107Nuclear receptor coactivator 1NCOA1Q15788
108Protooncogene serine/threonine-protein kinase Pim-1PIM1P11309
109Serine/threonine-protein kinase Chk1CHEK1O14757
1105-Hydroxytryptamine 2A receptorHTR2AP28223
111Alpha-1A adrenergic receptorADRA1AP35348
112Alpha-1B adrenergic receptorADRA1BP35368
113Caspase-9CASP9P55211
114Dopamine D1 receptorDRD1Q95136
115Gamma-aminobutyric-acid receptor alpha-3 subunitGABRA3P34903
116Gamma-aminobutyric-acid receptor alpha-5 subunitGABRA5P31644
117Muscarinic acetylcholine receptor M2CHRM2P08172
118Muscarinic acetylcholine receptor M3CHRM3P20309
119Muscarinic acetylcholine receptor M4CHRM4P08173
120Mu-type opioid receptorOPRM1P35372
121Neuronal acetylcholine receptor protein, alpha-7 chainCHRNA7P36544
122Neuronal acetylcholine receptor subunit alpha-2CHRNA2Q15822
123Sodium-dependent serotonin transporterSLC6A4P31645
124Transforming growth factor beta-1TGFB1P01137
125Aldo-keto reductase family 1 member C3AKR1C3P42330
126AntileukoproteinaseSLPIP03973
127Apoptosis regulator Bcl-2Bcl2P10417
128Aryl hydrocarbon receptorAhrP30561
129Cytochrome P450 1A2CYP1A2P05177
130Gamma-aminobutyric-acid receptor alpha-2 subunitGABRA2P47869
131Glutathione S-transferase Mu 2GSTM2P28161
132Hyaluronan synthase 2HAS2Q92819
133Inhibitor of nuclear factor kappa-B kinase subunit betaIKBKBO14920
134Mitogen-activated protein kinase 8MAPK8P45983
135Muscarinic acetylcholine receptor M1CHRM1P11229
136Nitric oxide synthase, endothelialNOS3P29474
137Nuclear receptor subfamily 1 group I member 2NR1I2O75469
138Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoformPIK3CGP48736
139Prostaglandin G/H synthase 2PTGS2P35354
140Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformPPP3CAQ08209
141Signal transducer and activator of transcription 1-alpha/betaSTAT1P42224
142Sodium-dependent noradrenaline transporterSLC6A2P23975
143Vascular cell adhesion protein 1VCAM1P19320
1444-Aminobutyrate aminotransferase, mitochondrialABATP80404
145Alcohol dehydrogenase 1AADH1AP07327
146Alcohol dehydrogenase 1BADH1BP00325
147Alcohol dehydrogenase 1CADH1CP00326
148Caspase-3CASP3P42574
149CD44 antigenCD44P16070
150Intercellular adhesion molecule 1ICAM1P05362
151Tumor necrosis factorTNFP01375
152Mineralocorticoid receptorNR3C2P08235
153Progesterone receptorPGRP06401