Review Article

Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases

Table 1

Similarities and differences between CD47 and CD36.

CytokinesFunctionsReferences
CD47(1) Binds with TSP-1 for antiangiogenesis
(2) As a “don’t eat me” signal, it blocks the phagocytosis of macrophages and causes cytosis
(3) Promoting osteoclast formation, angiogenesis, inflammation, apoptosis, and fibrosis by binding to TSP-1
Kaur et al. [34]
Wu et al. [35]
Kaur et al. [34]
Koduru et al. [67]

CD36(1) Anti-inflammatory and antiangiogenesis by binding to TSP-1
(2) Proinflammatory
(3) Profibrogenic
Wu et al. [35]
Rustenhoven et al. [68]
Koduru et al. [67]