Rosuvastatin Improves Cognitive Function of Chronic Hypertensive Rats by Attenuating White Matter Lesions and Beta-Amyloid Deposits
Rosuvastatin reduced the loss of tight junction proteins of blood-brain barrier in corpus callosum. (a) Representative images of vessels marked by ZO-1 (red) and Claudin-5 (green). Scale bar: 50 μm. (b) Quantitative analysis of the number of Claudin-5/ZO-1-positive vessels. (c) Representative images of vessels marked by Occludin (red) and Claudin-5 (green). Scale bar: 50 μm. (d) Quantitative analysis of the number of Claudin-5/Occludin-positive vessels. RHRSP/veh vs. sham-operated rats, .#RHRSP/ros vs. RHRSP/veh, . in RHRSP/veh and RHRSP/ros; in the sham-operated group.
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