Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress
Punicalagin regulates NF-κB signaling. Punicalagin downregulated activation of NF-κB (a, b) and inhibitor kinases of NF-κB signaling following AS (a, c). Representative immunoblot. (a) Expression levels of test proteins relative of control expressions set at 100% (the expression of phosphorylated proteins was normalized by respective nonphosphorylated protein expression). The results are presented as the (). represents vs. normal control; # represents vs. AS control. A–E represent the mean values from different experimental groups that differ at . L1: control; L2: AS control; L3: punicalagin (12.5 mg/kg body weight)+AS; L4: punicalagin (25 mg/kg body weight)+AS; L5: punicalagin (50 mg/kg body weight)+AS; L6: punicalagin (50 mg/kg body weight).
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