Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension

Table 1

The effects of L-norvaline on some blood and urine components in hypertensive (ISIAH) and normotensive (Wistar) rats on the seventh treatment day. Values are expressed as the mean ± SEM, .

Rat strain	ISIAH		Wistar
Type of treatment	Control	Norvaline	Control	Norvaline
Creatinine in urine mmol/l	7,35 ± 0,51	5,39 ± 0,56	5,87 ± 0,98	10,08 ± 1,13
Creatinine excretion μmol/day	95 ± 6,0	102 ± 9,5	92 ± 2,6	92 ± 5,1
Creatinine in plasma μmol/l	42,4 ± 2,5	38,8 ± 1,4	37,2 ± 2,3	37,1 ± 1,7
Glomerular filtration rate ml/min per 100 g body mass	0,42 ± 0,05	0,42 ± 0,047	0,48 ± 0,036	0,48 ± 0,02
Uric acid in urine μmol/l	496 ± 67	671 ± 49	450 ± 91	449 ± 41
Uric acid in plasma μmol/l	34,6 ± 7,4	33,8 ± 1.3	36,6 ± 2,7	41,6 ± 8,3
UN in urine mmol/l	971 ± 4,3	706 ± 98,3	919 ± 219,6	1391 ± 111
UN in plasma mmol/l	6,79 ± 0,29	6,8 ± 0,49	5,97 ± 0,57	5,29 ± 0,48
Urea in urine mmol/l	1031 ± 48,1	825 ± 81,1	840 ± 179,7	1269,2 ± 68,5
Urea excretion mmol/day	13,63 ± 1,24	17,0 ± 2,05	12,5 ± 1,15	12,1 ± 1,15
Urea in plasma mmol/l	7,04 ± 0,33	7,18 ± 1,13	6,24 ± 0,59	6,52 ± 0,92