Research Article
A System Biology-Based Approach for Designing Combination Therapy in Cancer Precision Medicine
Figure 11
An example plot of (upper) and (bottom) against iterations in a typical simulation. The formation and development of necrotic layer are manifested by tracking the changes in the slope of the curves. Evident change of the slope of the curve occurs at around the 60th iteration, and after that, random walk search by IAs is initiated.