Macrophage Depletion Improves Endothelial Insulin Resistance and Protects against Cardiovascular Injury in Salt-Sensitive Hypertension
The depletion of macrophage by LEC attenuated cardiac hypertrophy (a–c) and cardiac fibrosis (d, e) in hypertensive DS rats. The cardiac hypertrophy was assessed by heart weight (a) and cardiomyocyte sectional area (b, c). The representative images of cardiomyocyte sectional area stained with hematoxylin and eosin (b), the quantitative analysis of cardiomyocyte sectional area (c), the representative images of heart section stained with Masson’s trichrome for evaluation of cardiac fibrosis (d), and the quantitative assessment of the positive collagen-staining area in the heart (e). Statistical comparisons were performed by one-way ANOVA followed by the Bonferroni correction for multiple comparisons between groups. , vs. NS group, # vs. HS group.
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