Macrophage Depletion Improves Endothelial Insulin Resistance and Protects against Cardiovascular Injury in Salt-Sensitive Hypertension
The macrophage depletion by LEC improved vascular insulin signaling through IRS1/Akt/eNOS in hypertensive DS rats. The aortic tissues were incubated with insulin (100 nmol/L) for 30 minutes to stimulate insulin signaling. The protein expression of phosphor-IRS1 (Ser 612, a), phosphor-Akt (Tyr 473, b), and phosphor-eNOS (Ser 1177, c) was assessed by Western blot. Statistical comparisons were performed by one-way ANOVA followed by the Bonferroni correction for multiple comparisons between groups. , vs. NS group, # vs. HS group.
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