Ethnicity-Stratified Analysis of the Association between TNF-α Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis

Table 2

Summary of pooled ORs in the meta-analysis.

Comparison model	Studies	Overall effect		Heterogeneity
		OR (95% CI)	value		value
TNF-α rs1800629
Allelic model (A vs. G)
Overall	7	1.33 (0.98-1.81)	0.066	78.8%	<0.001
Asian	2	1.93 (1.59-2.35)	<0.001	0.0%	0.737
Caucasian	5	1.04 (0.91-1.20)	0.529	0.0%	0.617
Heterozygous model (GA vs. GG)
Overall	7	1.43 (1.05-1.96)	0.025	72.7%	0.001
Asian	2	1.94 (1.57-2.40)	<0.001	0.0%	0.975
Caucasian	5	1.18 (0.92-1.51)	0.188	24.0%	0.261
Homozygous model (AA vs. GG)
Overall	7	1.08 (0.72-1.62)	0.705	46.3%	0.097
Asian	2	3.65 (1.34-9.92)	0.011	0.0%	0.709
Caucasian	5	0.82 (0.52-1.30)	0.408	0.0%	0.682
Dominant model (AA+GA vs. GG)
Overall	7	1.42 (1.02-1.96)	0.036	76.0%	<0.001
Asian	2	1.99 (1.62-2.46)	<0.001	0.0%	0.864
Caucasian	5	1.10 (0.93-1.30)	0.289	3.2%	0.389
Recessive model (AA vs. GA+GG)
Overall	7	1.03 (0.69-1.53)	0.898	46.0%	0.099
Asian	2	3.30 (1.22-8.93)	0.019	0.0%	0.724
Caucasian	5	0.79 (0.50-1.25)	0.318	0.0%	0.543
TNF-α rs1799964
Allelic model (C vs. T)
Overall (Asian)	3	1.26 (1.11-1.43)	<0.001	43.8%	0.169
Heterozygous model (TC vs. TT)
Overall (Asian)	3	1.18 (1.00-1.39)	0.045	0.0%	0.727
Homozygous model (CC vs. TT)
Overall (Asian)	3	1.82 (1.28-2.59)	0.001	9.8%	0.330
Dominant model (CC+TC vs. TT)
Overall (Asian)	3	1.25 (1.07-1.46)	0.005	0.0%	0.431
Recessive model (CC vs. TC+TT)
Overall (Asian)	3	1.72 (1.22-2.44)	0.002	8.1%	0.337