Decreased ALKBH5, FTO, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis

Figure 1

Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) determined the mRNA expression of methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms’ tumor 1-associating protein (WTAP), A-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5), fat mass and obesity-associated protein (FTO), and YT521-B homology domains 2 (YTHDF2) in the peripheral blood from 20 rheumatoid arthritis (RA) and 20 controls (CON). The average expression of METTL3 (a), METTL14 (b), and WTAP (c) did not show any remarkable differences between patients with RA and the CON. The average expression of ALKBH5 (d), FTO (e), and YTHDF2 (f) in patients with RA was significantly decreased than those in CON.

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