Decreased ALKBH5, FTO, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis

Figure 5

The correlations between the global m6A content and the mRNA expression of A-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5), fat mass and obesity-associated protein (FTO), and YT521-B homology domains 2 (YTHDF2) in the peripheral blood from rheumatoid arthritis (RA). The peripheral blood global m6A content was significantly increased in patients with RA compared to controls (CON) (a). The increased m6A contents negatively correlated with decreased mRNA expression of FTO (c) and did not correlated with decreased mRNA expression of ALKBH5 (b) and YTHDF2 (d).

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(b)

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