Sleep Deprivation and Neurological Disorders

Figure 3

Sleep is a vital phenomenon and an indicator of overall health. Normal sleep is very essential for memory and brain health since various neural circuits in the brain are involved in sleep. Sleep deprivation has evolved as a major threat in modern society. SD impairs LTP and molecules associated with memory and leads to cognitive dysfunction. SD also impairs the clearance of toxic metabolites produced in the brain and contributes to the pathophysiology of neurological disorders like AD, PD, and cerebral stroke. SD also causes an imbalance in the immune system and aggravates the pathophysiology of MS and glioma. It can be concluded that SD adversely affects various proteins, genes, and molecular cascades in neurodegenerative disorders.