BioMed Research International / 2020 / Article / Tab 1

Research Article

Regulatory Mechanisms of Coicis Semen on Bionetwork of Liver Cancer Based on Network Pharmacology

Table 1

Research report of Coicis Semen in treatment of liver cancer.

No.DosageMechanismsTargetLiterature

1Norcantharidin (NCTD) + Coix lacryma-jobi seed oil (CLSO) combinationCytotoxicity and apoptotic induction in human HepG2 and HepG2/ADM cellsHepal-1 hepatoma-bearing mice[12]
2Cy5/gal(oct)-C-MEsAsialoglycoprotein receptor-mediated endocytosisHepG2 xenograft-bearing nude mice[13]
3But-gal-CMEsStrong cytotoxicity and improved apoptosis inductionHepG2 cells model[14]
4Gal-C-MEsStrong cytotoxicity enhanced cellular uptake and improved apoptosis inductionHepG2 cells model[15]
5KanglaiteInduction of NF-κB-mediated gene transcription in CD4 T cellsTumor-bearing mice[16]
6Adlay extractsObvious proliferate inhibitionHuman liver cancer cells[17]
7Injectable extract from the seed of Coix lacryma-jobiThe expression of caspase-8 was elevated and prolongedHepG2 cells[18]
8Ethanolic extract of adlay branSuppress CYP enzyme activities and CYP protein expression in the liver and lungsSprague-Dawley rats[19]
9KanglaiteMediated through activation of the Fas/FasL pathwayHepG2[20]

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