Regulatory Mechanisms of Coicis Semen on Bionetwork of Liver Cancer Based on Network Pharmacology

Table 1

Research report of Coicis Semen in treatment of liver cancer.

No.	Dosage	Mechanisms	Target	Literature
1	Norcantharidin (NCTD) + Coix lacryma-jobi seed oil (CLSO) combination	Cytotoxicity and apoptotic induction in human HepG2 and HepG2/ADM cells	Hepal-1 hepatoma-bearing mice	[12]
2	Cy5/gal(oct)-C-MEs	Asialoglycoprotein receptor-mediated endocytosis	HepG2 xenograft-bearing nude mice	[13]
3	But-gal-CMEs	Strong cytotoxicity and improved apoptosis induction	HepG2 cells model	[14]
4	Gal-C-MEs	Strong cytotoxicity enhanced cellular uptake and improved apoptosis induction	HepG2 cells model	[15]
5	Kanglaite	Induction of NF-κB-mediated gene transcription in CD4 T cells	Tumor-bearing mice	[16]
6	Adlay extracts	Obvious proliferate inhibition	Human liver cancer cells	[17]
7	Injectable extract from the seed of Coix lacryma-jobi	The expression of caspase-8 was elevated and prolonged	HepG2 cells	[18]
8	Ethanolic extract of adlay bran	Suppress CYP enzyme activities and CYP protein expression in the liver and lungs	Sprague-Dawley rats	[19]
9	Kanglaite	Mediated through activation of the Fas/FasL pathway	HepG2	[20]